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Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy
OBJECTIVES: To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648212/ https://www.ncbi.nlm.nih.gov/pubmed/29049405 http://dx.doi.org/10.1371/journal.pone.0186741 |
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author | Yoo, Yung Ju Hwang, Jeong-Min Yang, Hee Kyung |
author_facet | Yoo, Yung Ju Hwang, Jeong-Min Yang, Hee Kyung |
author_sort | Yoo, Yung Ju |
collection | PubMed |
description | OBJECTIVES: To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dynamic pupillometer (PLR-200; NeurOptics Inc., Irvine, USA). Age-matched controls included 58 healthy individuals with normal vision and optic nerve function. Pupil diameters, latency, constriction ratio, constriction velocity and dilation velocity were noted. The differences in PLR measurements were compared among the acute and chronic phases of ON and NAION, and in age-matched controls. Regression analysis determined factors associated with PLR measurements, including visual acuity, color vision defect, visual field defects and retinal nerve fiber layer thickness measurements on optical coherence tomography. RESULTS: Pupillary constriction velocity, constriction ratio and latency were all significantly decreased in the acute phase of ON and NAION. ON showed significantly delayed constriction latency compared to NAION (P = 0.047). Pupillary constriction velocity, constriction ratio and latency were recovered in the chronic phase of ON (P = 0.038, 0.018, and 0.045), however, these parameters were not recovered in NAION (P = 0.693, 0.173 and 0.994). CONCLUSIONS: Pupillary constriction velocity, constriction ratio, and latency were significantly decreased in the acute phase of ON and NAION compared to normal controls. ON showed delayed constriction latency compared to NAION. Decreased PLR were recovered in the chronic phase of ON, but not in NAION. |
format | Online Article Text |
id | pubmed-5648212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56482122017-11-03 Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy Yoo, Yung Ju Hwang, Jeong-Min Yang, Hee Kyung PLoS One Research Article OBJECTIVES: To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dynamic pupillometer (PLR-200; NeurOptics Inc., Irvine, USA). Age-matched controls included 58 healthy individuals with normal vision and optic nerve function. Pupil diameters, latency, constriction ratio, constriction velocity and dilation velocity were noted. The differences in PLR measurements were compared among the acute and chronic phases of ON and NAION, and in age-matched controls. Regression analysis determined factors associated with PLR measurements, including visual acuity, color vision defect, visual field defects and retinal nerve fiber layer thickness measurements on optical coherence tomography. RESULTS: Pupillary constriction velocity, constriction ratio and latency were all significantly decreased in the acute phase of ON and NAION. ON showed significantly delayed constriction latency compared to NAION (P = 0.047). Pupillary constriction velocity, constriction ratio and latency were recovered in the chronic phase of ON (P = 0.038, 0.018, and 0.045), however, these parameters were not recovered in NAION (P = 0.693, 0.173 and 0.994). CONCLUSIONS: Pupillary constriction velocity, constriction ratio, and latency were significantly decreased in the acute phase of ON and NAION compared to normal controls. ON showed delayed constriction latency compared to NAION. Decreased PLR were recovered in the chronic phase of ON, but not in NAION. Public Library of Science 2017-10-19 /pmc/articles/PMC5648212/ /pubmed/29049405 http://dx.doi.org/10.1371/journal.pone.0186741 Text en © 2017 Yoo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yoo, Yung Ju Hwang, Jeong-Min Yang, Hee Kyung Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title | Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title_full | Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title_fullStr | Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title_full_unstemmed | Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title_short | Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
title_sort | differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648212/ https://www.ncbi.nlm.nih.gov/pubmed/29049405 http://dx.doi.org/10.1371/journal.pone.0186741 |
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