An inducible mouse model of podocin-mutation-related nephrotic syndrome

Mutations in the NPHS2 gene, encoding podocin, cause hereditary nephrotic syndrome. The most common podocin mutation, R138Q, is associated with early disease onset and rapid progression to end-stage renal disease. Knock-in mice carrying a R140Q mutation, the mouse analogue of human R138Q, show devel...

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Detalles Bibliográficos
Autores principales: Tabatabaeifar, Mansoureh, Wlodkowski, Tanja, Simic, Ivana, Denc, Helga, Mollet, Geraldine, Weber, Stefanie, Moyers, John Julius, Brühl, Barbara, Randles, Michael Joseph, Lennon, Rachel, Antignac, Corinne, Schaefer, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648285/
https://www.ncbi.nlm.nih.gov/pubmed/29049388
http://dx.doi.org/10.1371/journal.pone.0186574

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