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Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation?
There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possible indirect descending effects of altered mood state on pai...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648334/ https://www.ncbi.nlm.nih.gov/pubmed/29057372 http://dx.doi.org/10.1016/j.ynpai.2017.03.002 |
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author | Frangos, Eleni Richards, Emily A. Bushnell, M. Catherine |
author_facet | Frangos, Eleni Richards, Emily A. Bushnell, M. Catherine |
author_sort | Frangos, Eleni |
collection | PubMed |
description | There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possible indirect descending effects of altered mood state on pain perception. This possibility is important, since previous studies have shown that mood state affects pain, particularly the affective dimension (pain unpleasantness). To date, human studies investigating the effects of vagus nerve stimulation on pain perception have not reliably measured psychological factors to determine their role in altered pain perception elicited by vagus nerve stimulation. Thus, it remains unclear how much of a role psychological factors play in vagal pain modulation. Here, we present a rationale for including psychological measures in future vagus nerve stimulation studies on pain. |
format | Online Article Text |
id | pubmed-5648334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56483342018-05-17 Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? Frangos, Eleni Richards, Emily A. Bushnell, M. Catherine Neurobiol Pain Mini-Reviews There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possible indirect descending effects of altered mood state on pain perception. This possibility is important, since previous studies have shown that mood state affects pain, particularly the affective dimension (pain unpleasantness). To date, human studies investigating the effects of vagus nerve stimulation on pain perception have not reliably measured psychological factors to determine their role in altered pain perception elicited by vagus nerve stimulation. Thus, it remains unclear how much of a role psychological factors play in vagal pain modulation. Here, we present a rationale for including psychological measures in future vagus nerve stimulation studies on pain. Elsevier 2017-03-31 /pmc/articles/PMC5648334/ /pubmed/29057372 http://dx.doi.org/10.1016/j.ynpai.2017.03.002 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Mini-Reviews Frangos, Eleni Richards, Emily A. Bushnell, M. Catherine Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title | Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title_full | Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title_fullStr | Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title_full_unstemmed | Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title_short | Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
title_sort | do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? |
topic | Mini-Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648334/ https://www.ncbi.nlm.nih.gov/pubmed/29057372 http://dx.doi.org/10.1016/j.ynpai.2017.03.002 |
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