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Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand
OBJECTIVE: The aim of this study was to investigate the association between genotype and haplotype of MDR1 (C1236T, G2677T/A and C3435T) and the risk for cervical cancer in Northeastern Thai women. METHODS: An age-matched case-control study involving squamous cell cervical cancer (SCCA) patients (n=...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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West Asia Organization for Cancer Prevention
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648384/ https://www.ncbi.nlm.nih.gov/pubmed/28749110 http://dx.doi.org/10.22034/APJCP.2017.18.7.1815 |
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author | Phuthong, Sophida Settheetham-Ishida, Wannapa Natphopsuk, Sitakan Settheetham, Dariwan Ishida, Takafumi |
author_facet | Phuthong, Sophida Settheetham-Ishida, Wannapa Natphopsuk, Sitakan Settheetham, Dariwan Ishida, Takafumi |
author_sort | Phuthong, Sophida |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to investigate the association between genotype and haplotype of MDR1 (C1236T, G2677T/A and C3435T) and the risk for cervical cancer in Northeastern Thai women. METHODS: An age-matched case-control study involving squamous cell cervical cancer (SCCA) patients (n=204) and healthy controls (n=204) was enrolled for MDR1 genotyping by real-time PCR method. RESULTS: The genotype distribution of MDR1 in both patients and controls was not significantly different (p>0.05). The haplotype analysis showed that T-T-T was the most common haplotype in this population. Significantly increased risk of cervical cancer was observed in carriers of T-T-C and C-G-T haplotypes with ORs of 1.86 (95%CI=1.02-3.39, p=0.0416) and 2.00 (95%CI=1.18-3.40, p=0.0140), respectively. Analysis of 2677-3435 haplotype showed increased risk for cervical cancer in G-T (OR=1.55; 95% CI=1.12-2.13, p=0.0432) and T-C (OR=1.91; 95%CI=1.05-3.47, p=0.0325). CONCLUSION: The results provide evidence that haplotype of MDR1 may be an important risk factor for cervical cancer development in Northeastern Thai women. |
format | Online Article Text |
id | pubmed-5648384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-56483842017-10-31 Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand Phuthong, Sophida Settheetham-Ishida, Wannapa Natphopsuk, Sitakan Settheetham, Dariwan Ishida, Takafumi Asian Pac J Cancer Prev Research Article OBJECTIVE: The aim of this study was to investigate the association between genotype and haplotype of MDR1 (C1236T, G2677T/A and C3435T) and the risk for cervical cancer in Northeastern Thai women. METHODS: An age-matched case-control study involving squamous cell cervical cancer (SCCA) patients (n=204) and healthy controls (n=204) was enrolled for MDR1 genotyping by real-time PCR method. RESULTS: The genotype distribution of MDR1 in both patients and controls was not significantly different (p>0.05). The haplotype analysis showed that T-T-T was the most common haplotype in this population. Significantly increased risk of cervical cancer was observed in carriers of T-T-C and C-G-T haplotypes with ORs of 1.86 (95%CI=1.02-3.39, p=0.0416) and 2.00 (95%CI=1.18-3.40, p=0.0140), respectively. Analysis of 2677-3435 haplotype showed increased risk for cervical cancer in G-T (OR=1.55; 95% CI=1.12-2.13, p=0.0432) and T-C (OR=1.91; 95%CI=1.05-3.47, p=0.0325). CONCLUSION: The results provide evidence that haplotype of MDR1 may be an important risk factor for cervical cancer development in Northeastern Thai women. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5648384/ /pubmed/28749110 http://dx.doi.org/10.22034/APJCP.2017.18.7.1815 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Phuthong, Sophida Settheetham-Ishida, Wannapa Natphopsuk, Sitakan Settheetham, Dariwan Ishida, Takafumi Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title | Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title_full | Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title_fullStr | Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title_full_unstemmed | Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title_short | Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern Thailand |
title_sort | haplotype analysis of mdr1 and risk for cervical cancer in northeastern thailand |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648384/ https://www.ncbi.nlm.nih.gov/pubmed/28749110 http://dx.doi.org/10.22034/APJCP.2017.18.7.1815 |
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