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Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro
Novel natural products 7R, 8R, 7′R, 9′S-verniciasin A (1a), 7S, 8S, 7′S, 9′R- verniciasin A (1b), 7R, 8R, 7′R, 9′S−7′-methoxylverniciasin A (2a) and 7S, 8S, 7′S, 9′R−7′-methoxylverniciasin A (2b) were characterized from the seed capsule of Vernicia fordii. And the unique 9-O-9′−7, 9′-cyclo-8, 1′-neo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648763/ https://www.ncbi.nlm.nih.gov/pubmed/29051580 http://dx.doi.org/10.1038/s41598-017-14062-z |
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author | Zhao, Wei-Hong Li, Ning Chu, Yang Sun, Tao Wang, Jian Wang, Wen-Li Li, Jia-Yuan Lin, Bin Chen, Ru Hou, Yue |
author_facet | Zhao, Wei-Hong Li, Ning Chu, Yang Sun, Tao Wang, Jian Wang, Wen-Li Li, Jia-Yuan Lin, Bin Chen, Ru Hou, Yue |
author_sort | Zhao, Wei-Hong |
collection | PubMed |
description | Novel natural products 7R, 8R, 7′R, 9′S-verniciasin A (1a), 7S, 8S, 7′S, 9′R- verniciasin A (1b), 7R, 8R, 7′R, 9′S−7′-methoxylverniciasin A (2a) and 7S, 8S, 7′S, 9′R−7′-methoxylverniciasin A (2b) were characterized from the seed capsule of Vernicia fordii. And the unique 9-O-9′−7, 9′-cyclo-8, 1′-neolignan skeleton with a seven-membered ring, was identified by extensive spectroscopic analysis. Further the possible biosynthetic pathway was briefly discussed. Interestingly, 1a, 2a, 1b and 2b all exhibited significant stereoselective inhibitory effects on NO production in LPS-induced BV2 microglia cell. Then the primary mechanism of the bioactivities and stereoselectivity was explored by means of bioassay and molecular docking. |
format | Online Article Text |
id | pubmed-5648763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56487632017-10-26 Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro Zhao, Wei-Hong Li, Ning Chu, Yang Sun, Tao Wang, Jian Wang, Wen-Li Li, Jia-Yuan Lin, Bin Chen, Ru Hou, Yue Sci Rep Article Novel natural products 7R, 8R, 7′R, 9′S-verniciasin A (1a), 7S, 8S, 7′S, 9′R- verniciasin A (1b), 7R, 8R, 7′R, 9′S−7′-methoxylverniciasin A (2a) and 7S, 8S, 7′S, 9′R−7′-methoxylverniciasin A (2b) were characterized from the seed capsule of Vernicia fordii. And the unique 9-O-9′−7, 9′-cyclo-8, 1′-neolignan skeleton with a seven-membered ring, was identified by extensive spectroscopic analysis. Further the possible biosynthetic pathway was briefly discussed. Interestingly, 1a, 2a, 1b and 2b all exhibited significant stereoselective inhibitory effects on NO production in LPS-induced BV2 microglia cell. Then the primary mechanism of the bioactivities and stereoselectivity was explored by means of bioassay and molecular docking. Nature Publishing Group UK 2017-10-19 /pmc/articles/PMC5648763/ /pubmed/29051580 http://dx.doi.org/10.1038/s41598-017-14062-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Wei-Hong Li, Ning Chu, Yang Sun, Tao Wang, Jian Wang, Wen-Li Li, Jia-Yuan Lin, Bin Chen, Ru Hou, Yue Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title | Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title_full | Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title_fullStr | Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title_full_unstemmed | Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title_short | Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro |
title_sort | novel cycloneolignans from vernicia fordii with inhibitory effects on over-activation of bv2 cells in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648763/ https://www.ncbi.nlm.nih.gov/pubmed/29051580 http://dx.doi.org/10.1038/s41598-017-14062-z |
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