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Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light
An organic-inorganic hybrid core-shell nanostructure, based on mesoporous silica coated upconversion core-shell nanoparticles (NaGdF(4):Yb,Er@NaGdF(4):Yb@mSiO(2)-Dopa abbreviated here as UCNP@mSiO(2)-Dopa) that stably incorporates dopamine (Dopa) in the silica layer was introduced as a theranostic n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648774/ https://www.ncbi.nlm.nih.gov/pubmed/29051529 http://dx.doi.org/10.1038/s41598-017-13284-5 |
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author | Lv, Ruichan Yang, Piaoping Chen, Guanying Gai, Shili Xu, Jiating Prasad, Paras N. |
author_facet | Lv, Ruichan Yang, Piaoping Chen, Guanying Gai, Shili Xu, Jiating Prasad, Paras N. |
author_sort | Lv, Ruichan |
collection | PubMed |
description | An organic-inorganic hybrid core-shell nanostructure, based on mesoporous silica coated upconversion core-shell nanoparticles (NaGdF(4):Yb,Er@NaGdF(4):Yb@mSiO(2)-Dopa abbreviated here as UCNP@mSiO(2)-Dopa) that stably incorporates dopamine (Dopa) in the silica layer was introduced as a theranostic nanoplatform for optical imaging guided photothermal therapy (PTT) using NIR excitation. Silica-attaching polyethylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs light under single 980 nm irradiation. We show that the activated UCNP@mSiO(2)-Dopa nanoplatform is able to produce a pronounced photothermal effect, that elevates water temperature from room temperature to 41.8 °C within 2 minutes, while concurrently emitting strong upconverted luminescence (UCL) for visualized guidance under 980 nm laser. In addition, we demonstrate the application of the same UCNP@mSiO(2)-Dopa nanoplatform for magnetic resonance imaging (MRI) and x-ray computed tomography (CT) enabled by the gadolinium (Gd) element contained in the UCNP. Importantly, the in vitro and in vivo anti-cancer therapeutic effects have been shown efficacious, implying the use of the described nanoplatform as an effective multi-modal imaging enabled PTT agent. Results from the in vivo biodistribution of UCNPs@mSiO(2), cellular live/dead assay, and histologic analysis of main organs of treated mice, reveal that the UCNP@mSiO(2)-Dopa agents are bio-compatible with low toxicity. |
format | Online Article Text |
id | pubmed-5648774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56487742017-10-26 Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light Lv, Ruichan Yang, Piaoping Chen, Guanying Gai, Shili Xu, Jiating Prasad, Paras N. Sci Rep Article An organic-inorganic hybrid core-shell nanostructure, based on mesoporous silica coated upconversion core-shell nanoparticles (NaGdF(4):Yb,Er@NaGdF(4):Yb@mSiO(2)-Dopa abbreviated here as UCNP@mSiO(2)-Dopa) that stably incorporates dopamine (Dopa) in the silica layer was introduced as a theranostic nanoplatform for optical imaging guided photothermal therapy (PTT) using NIR excitation. Silica-attaching polyethylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs light under single 980 nm irradiation. We show that the activated UCNP@mSiO(2)-Dopa nanoplatform is able to produce a pronounced photothermal effect, that elevates water temperature from room temperature to 41.8 °C within 2 minutes, while concurrently emitting strong upconverted luminescence (UCL) for visualized guidance under 980 nm laser. In addition, we demonstrate the application of the same UCNP@mSiO(2)-Dopa nanoplatform for magnetic resonance imaging (MRI) and x-ray computed tomography (CT) enabled by the gadolinium (Gd) element contained in the UCNP. Importantly, the in vitro and in vivo anti-cancer therapeutic effects have been shown efficacious, implying the use of the described nanoplatform as an effective multi-modal imaging enabled PTT agent. Results from the in vivo biodistribution of UCNPs@mSiO(2), cellular live/dead assay, and histologic analysis of main organs of treated mice, reveal that the UCNP@mSiO(2)-Dopa agents are bio-compatible with low toxicity. Nature Publishing Group UK 2017-10-19 /pmc/articles/PMC5648774/ /pubmed/29051529 http://dx.doi.org/10.1038/s41598-017-13284-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lv, Ruichan Yang, Piaoping Chen, Guanying Gai, Shili Xu, Jiating Prasad, Paras N. Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title | Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title_full | Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title_fullStr | Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title_full_unstemmed | Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title_short | Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
title_sort | dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648774/ https://www.ncbi.nlm.nih.gov/pubmed/29051529 http://dx.doi.org/10.1038/s41598-017-13284-5 |
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