MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg(2+)]i) levels. It has been shown that MAGT1 was involved in the disorder in Mg(2+) homeostasis after Epstein-Barr virus (EBV) infection. Here, we identified the effects of MAGT1-mediated disturbanc...

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Autores principales: Diao, Bo, Huang, Xiaoyong, Guo, Shen, Yang, Chengying, Liu, Guosong, Chen, Yongwen, Wu, Yuzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648775/
https://www.ncbi.nlm.nih.gov/pubmed/29051561
http://dx.doi.org/10.1038/s41598-017-11522-4
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author Diao, Bo
Huang, Xiaoyong
Guo, Shen
Yang, Chengying
Liu, Guosong
Chen, Yongwen
Wu, Yuzhang
author_facet Diao, Bo
Huang, Xiaoyong
Guo, Shen
Yang, Chengying
Liu, Guosong
Chen, Yongwen
Wu, Yuzhang
author_sort Diao, Bo
collection PubMed
description The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg(2+)]i) levels. It has been shown that MAGT1 was involved in the disorder in Mg(2+) homeostasis after Epstein-Barr virus (EBV) infection. Here, we identified the effects of MAGT1-mediated disturbance of Mg(2+) homeostasis on chronic hepatitis B virus (HBV)-infected natural killer (NK) and CD8(+) T cells. The expression of MAGT1 was gradually decreased with the increase of infected time in CD8(+) T cells, but not with that in NK cells, of the patients. Decreased level of intracellular free Mg(2+) ([Mg(2+)]i) leads to defective expression of programmed cell death 1 (PD-1) and the NK activating receptor (NKG2D) in NK and CD8(+) T cells. Our data illustrate that [Mg(2+)]i plays a key role in control of HBV infection.
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spelling pubmed-56487752017-10-26 MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells Diao, Bo Huang, Xiaoyong Guo, Shen Yang, Chengying Liu, Guosong Chen, Yongwen Wu, Yuzhang Sci Rep Article The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg(2+)]i) levels. It has been shown that MAGT1 was involved in the disorder in Mg(2+) homeostasis after Epstein-Barr virus (EBV) infection. Here, we identified the effects of MAGT1-mediated disturbance of Mg(2+) homeostasis on chronic hepatitis B virus (HBV)-infected natural killer (NK) and CD8(+) T cells. The expression of MAGT1 was gradually decreased with the increase of infected time in CD8(+) T cells, but not with that in NK cells, of the patients. Decreased level of intracellular free Mg(2+) ([Mg(2+)]i) leads to defective expression of programmed cell death 1 (PD-1) and the NK activating receptor (NKG2D) in NK and CD8(+) T cells. Our data illustrate that [Mg(2+)]i plays a key role in control of HBV infection. Nature Publishing Group UK 2017-10-19 /pmc/articles/PMC5648775/ /pubmed/29051561 http://dx.doi.org/10.1038/s41598-017-11522-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Diao, Bo
Huang, Xiaoyong
Guo, Shen
Yang, Chengying
Liu, Guosong
Chen, Yongwen
Wu, Yuzhang
MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title_full MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title_fullStr MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title_full_unstemmed MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title_short MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells
title_sort magt1-mediated disturbance of mg(2+) homeostasis lead to exhausted of hbv-infected nk and cd8(+) t cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648775/
https://www.ncbi.nlm.nih.gov/pubmed/29051561
http://dx.doi.org/10.1038/s41598-017-11522-4
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