Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utr...

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Detalles Bibliográficos
Autores principales: Voit, Antanina, Patel, Vishwendra, Pachon, Ronald, Shah, Vikas, Bakhutma, Mohammad, Kohlbrenner, Erik, McArdle, Joseph J., Dell’Italia, Louis J., Mendell, Jerry R., Xie, Lai-Hua, Hajjar, Roger J., Duan, Dongsheng, Fraidenraich, Diego, Babu, Gopal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648780/
https://www.ncbi.nlm.nih.gov/pubmed/29051551
http://dx.doi.org/10.1038/s41467-017-01146-7

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