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Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice

Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgenic mouse line Actin-tTS::Nkcc1 (tetO/tetO) for manipulatable e...

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Detalles Bibliográficos
Autores principales:	Watabe, Takahisa, Xu, Ming, Watanabe, Miho, Nabekura, Junichi, Higuchi, Taiga, Hori, Karin, Sato, Mitsuo P., Nin, Fumiaki, Hibino, Hiroshi, Ogawa, Kaoru, Masuda, Masatsugu, Tanaka, Kenji F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648887/ https://www.ncbi.nlm.nih.gov/pubmed/29051615 http://dx.doi.org/10.1038/s41598-017-13997-7

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