FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

Interstrand cross-link (ICL) hypersensitivity is a characteristic trait of Fanconi anemia (FA). Although FANCD2-associated nuclease 1 (FAN1) contributes to ICL repair, FAN1 mutations predispose to karyomegalic interstitial nephritis (KIN) and cancer rather than to FA. Thus, the biological role of FA...

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Detalles Bibliográficos
Autores principales: Porro, Antonio, Berti, Matteo, Pizzolato, Julia, Bologna, Serena, Kaden, Svenja, Saxer, Anja, Ma, Yue, Nagasawa, Kazuo, Sartori, Alessandro A., Jiricny, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648898/
https://www.ncbi.nlm.nih.gov/pubmed/29051491
http://dx.doi.org/10.1038/s41467-017-01074-6

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