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Is biological repair of heart on the horizon?

The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Si...

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Detalles Bibliográficos
Autores principales: Ahmad, HR, Hashmi, Satwat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648936/
https://www.ncbi.nlm.nih.gov/pubmed/29067089
http://dx.doi.org/10.12669/pjms.334.12938
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author Ahmad, HR
Hashmi, Satwat
author_facet Ahmad, HR
Hashmi, Satwat
author_sort Ahmad, HR
collection PubMed
description The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Since stem cells can be cultured with a normal karyo type, they could be the ideal source for heart repair after myocardial infarction. As opposed to lower vertebrates and neonatal mice, cardiac regeneration in adult mammalian heart seems to be difficult to assess with a solid evidence of cytokinesis. It becomes more difficult to quantify the level of regeneration after myocardial infarction injury against a background of a large invasion of proliferating inflammatory cells. The question to beraised is how the renewal of a piece of myocardium follows the time line of picking upcell types in series: cardiomyocytes, endothelial cells, smooth muscle cells, fibroblast, pacemaker cells, conducting and Purkinje cells to bring the orchestration of rhythmically contracting and relaxing heart. This review focuses on where we are onthe status of heart repair and cardiac regeneration.
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spelling pubmed-56489362017-10-24 Is biological repair of heart on the horizon? Ahmad, HR Hashmi, Satwat Pak J Med Sci Review Article The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Since stem cells can be cultured with a normal karyo type, they could be the ideal source for heart repair after myocardial infarction. As opposed to lower vertebrates and neonatal mice, cardiac regeneration in adult mammalian heart seems to be difficult to assess with a solid evidence of cytokinesis. It becomes more difficult to quantify the level of regeneration after myocardial infarction injury against a background of a large invasion of proliferating inflammatory cells. The question to beraised is how the renewal of a piece of myocardium follows the time line of picking upcell types in series: cardiomyocytes, endothelial cells, smooth muscle cells, fibroblast, pacemaker cells, conducting and Purkinje cells to bring the orchestration of rhythmically contracting and relaxing heart. This review focuses on where we are onthe status of heart repair and cardiac regeneration. Professional Medical Publications 2017 /pmc/articles/PMC5648936/ /pubmed/29067089 http://dx.doi.org/10.12669/pjms.334.12938 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmad, HR
Hashmi, Satwat
Is biological repair of heart on the horizon?
title Is biological repair of heart on the horizon?
title_full Is biological repair of heart on the horizon?
title_fullStr Is biological repair of heart on the horizon?
title_full_unstemmed Is biological repair of heart on the horizon?
title_short Is biological repair of heart on the horizon?
title_sort is biological repair of heart on the horizon?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648936/
https://www.ncbi.nlm.nih.gov/pubmed/29067089
http://dx.doi.org/10.12669/pjms.334.12938
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