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Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports

Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm. Although MTSCC is considered to be a low-grade and indolent neoplasm, aggressive cases have been recently reported. The present study discussed two additional cases of high-grade MTSCC causing multipl...

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Autores principales: Uchida, Shiro, Suzuki, Koyu, Uno, Mieko, Nozaki, Fumi, Li, Chih-Ping, Abe, Eriko, Yamauchi, Teruo, Horiuchi, Saya, Kamo, Minobu, Hattori, Kazunori, Nagashima, Yoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649005/
https://www.ncbi.nlm.nih.gov/pubmed/29075488
http://dx.doi.org/10.3892/mco.2017.1400
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author Uchida, Shiro
Suzuki, Koyu
Uno, Mieko
Nozaki, Fumi
Li, Chih-Ping
Abe, Eriko
Yamauchi, Teruo
Horiuchi, Saya
Kamo, Minobu
Hattori, Kazunori
Nagashima, Yoji
author_facet Uchida, Shiro
Suzuki, Koyu
Uno, Mieko
Nozaki, Fumi
Li, Chih-Ping
Abe, Eriko
Yamauchi, Teruo
Horiuchi, Saya
Kamo, Minobu
Hattori, Kazunori
Nagashima, Yoji
author_sort Uchida, Shiro
collection PubMed
description Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm. Although MTSCC is considered to be a low-grade and indolent neoplasm, aggressive cases have been recently reported. The present study discussed two additional cases of high-grade MTSCC causing multiple distant metastases with a fatal course. In case 1, a 71-year-old patient presented with hematuria and pyuria. Computed tomography (CT) scan of the right kidney revealed a mass lesion, for which partial nephrectomy was performed. However, a follow-up CT imaging revealed distant metastases in the liver, the paraaortic lymph nodes and the bone. Despite molecular targeted therapy and irradiation, the patient succumbed due to tumor progression. In case 2, a 64-year-old patient presented with an incidentally identified mass lesion in the right kidney. A laparoscopic nephrectomy was performed, and a follow-up CT imaging revealed metastases in the skin and lungs. The cytology of pleural effusion revealed pleuritis carcinomatosa. Histologically, both cases were diagnosed as mucin-poor MTSCC with high-grade transformation, which comprised uniform tumor cells primarily forming slender tubules. The tumors contained low- and high-grade regions. In addition, venous invasion and necrosis were observed. The tumor cells also demonstrated increased Ki-67 labeling indices and cellular tumor antigen p53 (p53) nuclear accumulation. High-grade transformation, large tumor size, necrosis, venous invasion, high Ki-67 labeling index and p53 nuclear accumulation are generally predictive findings for aggressive behavior of malignant tumors. In the current report, it was emphasized that MTSCC possesses a wide spectrum of clinicopathological features. Thus, careful postoperative investigation is required for MTSCC with high-grade elements due to its aggressive nature.
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spelling pubmed-56490052017-10-26 Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports Uchida, Shiro Suzuki, Koyu Uno, Mieko Nozaki, Fumi Li, Chih-Ping Abe, Eriko Yamauchi, Teruo Horiuchi, Saya Kamo, Minobu Hattori, Kazunori Nagashima, Yoji Mol Clin Oncol Articles Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm. Although MTSCC is considered to be a low-grade and indolent neoplasm, aggressive cases have been recently reported. The present study discussed two additional cases of high-grade MTSCC causing multiple distant metastases with a fatal course. In case 1, a 71-year-old patient presented with hematuria and pyuria. Computed tomography (CT) scan of the right kidney revealed a mass lesion, for which partial nephrectomy was performed. However, a follow-up CT imaging revealed distant metastases in the liver, the paraaortic lymph nodes and the bone. Despite molecular targeted therapy and irradiation, the patient succumbed due to tumor progression. In case 2, a 64-year-old patient presented with an incidentally identified mass lesion in the right kidney. A laparoscopic nephrectomy was performed, and a follow-up CT imaging revealed metastases in the skin and lungs. The cytology of pleural effusion revealed pleuritis carcinomatosa. Histologically, both cases were diagnosed as mucin-poor MTSCC with high-grade transformation, which comprised uniform tumor cells primarily forming slender tubules. The tumors contained low- and high-grade regions. In addition, venous invasion and necrosis were observed. The tumor cells also demonstrated increased Ki-67 labeling indices and cellular tumor antigen p53 (p53) nuclear accumulation. High-grade transformation, large tumor size, necrosis, venous invasion, high Ki-67 labeling index and p53 nuclear accumulation are generally predictive findings for aggressive behavior of malignant tumors. In the current report, it was emphasized that MTSCC possesses a wide spectrum of clinicopathological features. Thus, careful postoperative investigation is required for MTSCC with high-grade elements due to its aggressive nature. D.A. Spandidos 2017-11 2017-08-28 /pmc/articles/PMC5649005/ /pubmed/29075488 http://dx.doi.org/10.3892/mco.2017.1400 Text en Copyright: © Uchida et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Uchida, Shiro
Suzuki, Koyu
Uno, Mieko
Nozaki, Fumi
Li, Chih-Ping
Abe, Eriko
Yamauchi, Teruo
Horiuchi, Saya
Kamo, Minobu
Hattori, Kazunori
Nagashima, Yoji
Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title_full Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title_fullStr Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title_full_unstemmed Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title_short Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports
title_sort mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: two case reports
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649005/
https://www.ncbi.nlm.nih.gov/pubmed/29075488
http://dx.doi.org/10.3892/mco.2017.1400
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