Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report

Although chronic hepatitis C virus (HCV) infection affect 185 million people world-wide, pathomechanism of liver damage is still unclear. Electron microscopy can reveal liver injury in very early stage and help understanding the mechanisms that is crucial in the pathogenesis of chronic hepatitis C....

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Autores principales: Wieczorek, Anna, Stępień, Piotr M., Zarębska-Michaluk, Dorota, Kryczka, Wiesław, Pabjan, Paweł, Król, Teodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649480/
https://www.ncbi.nlm.nih.gov/pubmed/29062908
http://dx.doi.org/10.5114/ceh.2017.68287
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author Wieczorek, Anna
Stępień, Piotr M.
Zarębska-Michaluk, Dorota
Kryczka, Wiesław
Pabjan, Paweł
Król, Teodora
author_facet Wieczorek, Anna
Stępień, Piotr M.
Zarębska-Michaluk, Dorota
Kryczka, Wiesław
Pabjan, Paweł
Król, Teodora
author_sort Wieczorek, Anna
collection PubMed
description Although chronic hepatitis C virus (HCV) infection affect 185 million people world-wide, pathomechanism of liver damage is still unclear. Electron microscopy can reveal liver injury in very early stage and help understanding the mechanisms that is crucial in the pathogenesis of chronic hepatitis C. We present the morphological changes in the liver of HCV infected 24-year-old female patient, using light and transmission electron microscopy. Examination by TEM revealed wide range of specific subcellular abnormalities in hepatocellular ultrastructure. The most common observed changes were ring-shaped nuclei with intranuclear inclusion, megamitochondria, and “membranous web” structures – the hallmark of RNA-viruses infection.
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spelling pubmed-56494802017-10-23 Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report Wieczorek, Anna Stępień, Piotr M. Zarębska-Michaluk, Dorota Kryczka, Wiesław Pabjan, Paweł Król, Teodora Clin Exp Hepatol Case Report Although chronic hepatitis C virus (HCV) infection affect 185 million people world-wide, pathomechanism of liver damage is still unclear. Electron microscopy can reveal liver injury in very early stage and help understanding the mechanisms that is crucial in the pathogenesis of chronic hepatitis C. We present the morphological changes in the liver of HCV infected 24-year-old female patient, using light and transmission electron microscopy. Examination by TEM revealed wide range of specific subcellular abnormalities in hepatocellular ultrastructure. The most common observed changes were ring-shaped nuclei with intranuclear inclusion, megamitochondria, and “membranous web” structures – the hallmark of RNA-viruses infection. Termedia Publishing House 2017-06-12 2017-09 /pmc/articles/PMC5649480/ /pubmed/29062908 http://dx.doi.org/10.5114/ceh.2017.68287 Text en Copyright: © 2017 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Case Report
Wieczorek, Anna
Stępień, Piotr M.
Zarębska-Michaluk, Dorota
Kryczka, Wiesław
Pabjan, Paweł
Król, Teodora
Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title_full Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title_fullStr Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title_full_unstemmed Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title_short Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report
title_sort megamitochondria formation in hepatocytes of patient with chronic hepatitis c – a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649480/
https://www.ncbi.nlm.nih.gov/pubmed/29062908
http://dx.doi.org/10.5114/ceh.2017.68287
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