Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy

PURPOSE: The murine double minute (MDM)2 is a critical negative regulator of the p53 tumor suppressor, and MDM2 SNP309G is associated with a higher risk of proliferative vitreoretinopathy (PVR); in addition, the MDM2 T309G created using clustered regularly interspaced short palindromic repeats (CRIS...

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Detalles Bibliográficos
Autores principales: Zhou, Guohong, Duan, Yajiang, Ma, Gaoen, Wu, Wenyi, Hu, Zhengping, Chen, Na, Chee, Yewlin, Cui, Jing, Samad, Arif, Matsubara, Joanne A., Mukai, Shizuo, D'Amore, Patricia A., Lei, Hetian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649510/
https://www.ncbi.nlm.nih.gov/pubmed/29049737
http://dx.doi.org/10.1167/iovs.17-22045

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