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Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma

Hemophagocytic lymphohistiocytosis (HLH) or Macrophage Activation Syndrome (MAS) is a potentially life threatening disorder that presents with fever, suppressed blood cell counts, hepatosplenomegaly and multi-organ failure. HLH has been reported in association with genetic mutations, infections, aut...

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Autores principales: Nayudu, Suresh Kumar, Fida, Nadia, Acidera, Anna, Daniel, Myrta, Rudikoff, Donald, Niazi, Masooma, Chilimuri, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649666/
https://www.ncbi.nlm.nih.gov/pubmed/29147237
http://dx.doi.org/10.4021/wjon307w
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author Nayudu, Suresh Kumar
Fida, Nadia
Acidera, Anna
Daniel, Myrta
Rudikoff, Donald
Niazi, Masooma
Chilimuri, Sridhar
author_facet Nayudu, Suresh Kumar
Fida, Nadia
Acidera, Anna
Daniel, Myrta
Rudikoff, Donald
Niazi, Masooma
Chilimuri, Sridhar
author_sort Nayudu, Suresh Kumar
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) or Macrophage Activation Syndrome (MAS) is a potentially life threatening disorder that presents with fever, suppressed blood cell counts, hepatosplenomegaly and multi-organ failure. HLH has been reported in association with genetic mutations, infections, autoimmune disorders, and various malignancies. However to the best of our knowledge, HLH in association with Clostridium difficile infection has never been reported. We present a case of HLH in a patient with Epstein-Barr virus (EBV) positive natural killer T (NKT) cell cutaneous lymphoma and active Clostridium difficile infection. A 35-year-old male with recently diagnosed EBV positive NKT cell lymphoma was admitted for Clostridium difficile associated diarrhea. During the course of hospitalization he gradually developed pancytopenia and multi-organ failure leading to death. Post-mortem examination confirmed the diagnosis of hemophagocytic lymphohistiocytosis.
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spelling pubmed-56496662017-11-16 Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma Nayudu, Suresh Kumar Fida, Nadia Acidera, Anna Daniel, Myrta Rudikoff, Donald Niazi, Masooma Chilimuri, Sridhar World J Oncol Case Report Hemophagocytic lymphohistiocytosis (HLH) or Macrophage Activation Syndrome (MAS) is a potentially life threatening disorder that presents with fever, suppressed blood cell counts, hepatosplenomegaly and multi-organ failure. HLH has been reported in association with genetic mutations, infections, autoimmune disorders, and various malignancies. However to the best of our knowledge, HLH in association with Clostridium difficile infection has never been reported. We present a case of HLH in a patient with Epstein-Barr virus (EBV) positive natural killer T (NKT) cell cutaneous lymphoma and active Clostridium difficile infection. A 35-year-old male with recently diagnosed EBV positive NKT cell lymphoma was admitted for Clostridium difficile associated diarrhea. During the course of hospitalization he gradually developed pancytopenia and multi-organ failure leading to death. Post-mortem examination confirmed the diagnosis of hemophagocytic lymphohistiocytosis. Elmer Press 2011-06 2011-06-08 /pmc/articles/PMC5649666/ /pubmed/29147237 http://dx.doi.org/10.4021/wjon307w Text en Copyright 2011, Nayudu et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nayudu, Suresh Kumar
Fida, Nadia
Acidera, Anna
Daniel, Myrta
Rudikoff, Donald
Niazi, Masooma
Chilimuri, Sridhar
Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title_full Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title_fullStr Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title_full_unstemmed Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title_short Hemophagocytic Lymphohistiocytosis in Association With Clostridium difficile Infection and Cutaneous T-Cell Lymphoma
title_sort hemophagocytic lymphohistiocytosis in association with clostridium difficile infection and cutaneous t-cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649666/
https://www.ncbi.nlm.nih.gov/pubmed/29147237
http://dx.doi.org/10.4021/wjon307w
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