Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy

The blood-brain barrier is traditionally regarded as an insurmountable obstacle to the effective drug therapy of brain metastases from solid tumors. Here we describe a striking case of complete radiologic response to chemotherapy, and propose that the critical success factors include the large tumor...

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Detalles Bibliográficos
Autores principales: Brungs, Daniel, Sze, Victor, Emmett, Louise, Epstein, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649680/
https://www.ncbi.nlm.nih.gov/pubmed/29147343
http://dx.doi.org/10.4021/wjon639w
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author Brungs, Daniel
Sze, Victor
Emmett, Louise
Epstein, Richard J.
author_facet Brungs, Daniel
Sze, Victor
Emmett, Louise
Epstein, Richard J.
author_sort Brungs, Daniel
collection PubMed
description The blood-brain barrier is traditionally regarded as an insurmountable obstacle to the effective drug therapy of brain metastases from solid tumors. Here we describe a striking case of complete radiologic response to chemotherapy, and propose that the critical success factors include the large tumor size, HER2-positivity, and concomitant use of trastuzumab.
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spelling pubmed-56496802017-11-16 Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy Brungs, Daniel Sze, Victor Emmett, Louise Epstein, Richard J. World J Oncol Case Report The blood-brain barrier is traditionally regarded as an insurmountable obstacle to the effective drug therapy of brain metastases from solid tumors. Here we describe a striking case of complete radiologic response to chemotherapy, and propose that the critical success factors include the large tumor size, HER2-positivity, and concomitant use of trastuzumab. Elmer Press 2013-04 2013-05-06 /pmc/articles/PMC5649680/ /pubmed/29147343 http://dx.doi.org/10.4021/wjon639w Text en Copyright 2013, Brungs et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Brungs, Daniel
Sze, Victor
Emmett, Louise
Epstein, Richard J.
Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title_full Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title_fullStr Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title_full_unstemmed Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title_short Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy
title_sort complete radiologic response of bulky cerebral metastases from newly diagnosed her2-positive breast cancer to upfront trastuzumab-based chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649680/
https://www.ncbi.nlm.nih.gov/pubmed/29147343
http://dx.doi.org/10.4021/wjon639w
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