Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma

Carcinomatous meningitis (CM) is a devastating complication of advanced cancers. No standard treatment is available for CM secondary to solid tumors. In particular, very few data have been published for CM related to lung adenocarcinoma. Herein we report the case of a 39-year old woman treated for a...

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Autores principales: Clatot, Florian, David, Philippe, Laberge-Le-Couteulx, Sophie, Blot, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649689/
https://www.ncbi.nlm.nih.gov/pubmed/29147258
http://dx.doi.org/10.4021/wjon358w
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author Clatot, Florian
David, Philippe
Laberge-Le-Couteulx, Sophie
Blot, Emmanuel
author_facet Clatot, Florian
David, Philippe
Laberge-Le-Couteulx, Sophie
Blot, Emmanuel
author_sort Clatot, Florian
collection PubMed
description Carcinomatous meningitis (CM) is a devastating complication of advanced cancers. No standard treatment is available for CM secondary to solid tumors. In particular, very few data have been published for CM related to lung adenocarcinoma. Herein we report the case of a 39-year old woman treated for a metastatic lung adenocarcinoma, without EGFR mutation, complicated by a CM. Intrathecal administrations of high dose methotrexate produced both a clinical improvement of symptoms related to CM and an unusually delayed survival.
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spelling pubmed-56496892017-11-16 Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma Clatot, Florian David, Philippe Laberge-Le-Couteulx, Sophie Blot, Emmanuel World J Oncol Case Report Carcinomatous meningitis (CM) is a devastating complication of advanced cancers. No standard treatment is available for CM secondary to solid tumors. In particular, very few data have been published for CM related to lung adenocarcinoma. Herein we report the case of a 39-year old woman treated for a metastatic lung adenocarcinoma, without EGFR mutation, complicated by a CM. Intrathecal administrations of high dose methotrexate produced both a clinical improvement of symptoms related to CM and an unusually delayed survival. Elmer Press 2011-10 2011-10-28 /pmc/articles/PMC5649689/ /pubmed/29147258 http://dx.doi.org/10.4021/wjon358w Text en Copyright 2011, Clatot et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Clatot, Florian
David, Philippe
Laberge-Le-Couteulx, Sophie
Blot, Emmanuel
Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title_full Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title_fullStr Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title_full_unstemmed Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title_short Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
title_sort clinical improvement and prolonged survival with high dose intrathecal methotrexate for carcinomatous meningitis secondary to a lung adenocarcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649689/
https://www.ncbi.nlm.nih.gov/pubmed/29147258
http://dx.doi.org/10.4021/wjon358w
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