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Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?

Aromatase inhibitors (AIs) are the indispensible part of hormone-responsive breast cancer treatment. A potential relation between autoimmunity and AIs has been described before. Herein, we report a case of Sjogren’s syndrome (SjS) and polyneuropathy which developed during treatment with anastrozole....

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Detalles Bibliográficos
Autores principales: Yasar Bilge, Nazife Sule, Korkmaz, Cengiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649745/
https://www.ncbi.nlm.nih.gov/pubmed/29147400
http://dx.doi.org/10.14740/wjon695w
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author Yasar Bilge, Nazife Sule
Korkmaz, Cengiz
author_facet Yasar Bilge, Nazife Sule
Korkmaz, Cengiz
author_sort Yasar Bilge, Nazife Sule
collection PubMed
description Aromatase inhibitors (AIs) are the indispensible part of hormone-responsive breast cancer treatment. A potential relation between autoimmunity and AIs has been described before. Herein, we report a case of Sjogren’s syndrome (SjS) and polyneuropathy which developed during treatment with anastrozole. A 70 years old female patient having a history of breast cancer was referred to our clinic with numbness in both legs for 1 year. She was receiving anastrazole since 2006. She was having sicca symptoms for 3 years. After laboratory evaluation, salivary gland biopsy and electroneuromyography, the patient was evaluated as SjS and polyneuropathy. Intravenous immunoglobulin treatment (400 mg/kg/day, 5 days, 6 months) was initiated. A potential pathogenic linkage between AI therapy and autoimmunity is mentioned. Only few cases of rheumatoid arthritis and SjS related with AIs have been reported. But, our case is the first in the literature having definite SjS and neuropathy in this setting.
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spelling pubmed-56497452017-11-16 Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy? Yasar Bilge, Nazife Sule Korkmaz, Cengiz World J Oncol Case Report Aromatase inhibitors (AIs) are the indispensible part of hormone-responsive breast cancer treatment. A potential relation between autoimmunity and AIs has been described before. Herein, we report a case of Sjogren’s syndrome (SjS) and polyneuropathy which developed during treatment with anastrozole. A 70 years old female patient having a history of breast cancer was referred to our clinic with numbness in both legs for 1 year. She was receiving anastrazole since 2006. She was having sicca symptoms for 3 years. After laboratory evaluation, salivary gland biopsy and electroneuromyography, the patient was evaluated as SjS and polyneuropathy. Intravenous immunoglobulin treatment (400 mg/kg/day, 5 days, 6 months) was initiated. A potential pathogenic linkage between AI therapy and autoimmunity is mentioned. Only few cases of rheumatoid arthritis and SjS related with AIs have been reported. But, our case is the first in the literature having definite SjS and neuropathy in this setting. Elmer Press 2014-08 2014-08-25 /pmc/articles/PMC5649745/ /pubmed/29147400 http://dx.doi.org/10.14740/wjon695w Text en Copyright 2014, Yasar Bilge et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yasar Bilge, Nazife Sule
Korkmaz, Cengiz
Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title_full Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title_fullStr Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title_full_unstemmed Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title_short Does Aromatase Inhibitors Cause Sjogren’s Syndrome and Polyneuropathy?
title_sort does aromatase inhibitors cause sjogren’s syndrome and polyneuropathy?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649745/
https://www.ncbi.nlm.nih.gov/pubmed/29147400
http://dx.doi.org/10.14740/wjon695w
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