A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report

Bevacizumab is a recombinant monoclonal antibody against vascular endothelial growth factor (VEGF) that is used to treat metastatic cancers of the colon, rectum, kidney, and breast. Its side effects include proteinuria, hypertension, gastrointestinal perforations, and arterial emboli. Although these...

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Detalles Bibliográficos
Autores principales: Domenico, Germano, Vincenza, Tinessa, Emiddio, Barletta, Dino, Turitto, Franco, Muccio Carmine, Bruno, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649753/
https://www.ncbi.nlm.nih.gov/pubmed/29147218
http://dx.doi.org/10.4021/wjon265w
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author Domenico, Germano
Vincenza, Tinessa
Emiddio, Barletta
Dino, Turitto
Franco, Muccio Carmine
Bruno, Daniele
author_facet Domenico, Germano
Vincenza, Tinessa
Emiddio, Barletta
Dino, Turitto
Franco, Muccio Carmine
Bruno, Daniele
author_sort Domenico, Germano
collection PubMed
description Bevacizumab is a recombinant monoclonal antibody against vascular endothelial growth factor (VEGF) that is used to treat metastatic cancers of the colon, rectum, kidney, and breast. Its side effects include proteinuria, hypertension, gastrointestinal perforations, and arterial emboli. Although these toxic effects are more frequent in patients with atherosclerosis, their pathophysiology remains unresolved. We observed that patients treated with bevacizumab who developed hypertension had similar clinical presentations and biologic features, leading us to propose a unique mechanism for the vascular side effects of bevacizumab. We report a case of a woman treated for her metastatic breast cancer with first line chemotherapy with Paclitaxel plus bevacizumab who developed a brain stroke.
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spelling pubmed-56497532017-11-16 A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report Domenico, Germano Vincenza, Tinessa Emiddio, Barletta Dino, Turitto Franco, Muccio Carmine Bruno, Daniele World J Oncol Case Report Bevacizumab is a recombinant monoclonal antibody against vascular endothelial growth factor (VEGF) that is used to treat metastatic cancers of the colon, rectum, kidney, and breast. Its side effects include proteinuria, hypertension, gastrointestinal perforations, and arterial emboli. Although these toxic effects are more frequent in patients with atherosclerosis, their pathophysiology remains unresolved. We observed that patients treated with bevacizumab who developed hypertension had similar clinical presentations and biologic features, leading us to propose a unique mechanism for the vascular side effects of bevacizumab. We report a case of a woman treated for her metastatic breast cancer with first line chemotherapy with Paclitaxel plus bevacizumab who developed a brain stroke. Elmer Press 2010-12 2011-01-01 /pmc/articles/PMC5649753/ /pubmed/29147218 http://dx.doi.org/10.4021/wjon265w Text en Copyright 2010, Domenico et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Domenico, Germano
Vincenza, Tinessa
Emiddio, Barletta
Dino, Turitto
Franco, Muccio Carmine
Bruno, Daniele
A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title_full A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title_fullStr A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title_full_unstemmed A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title_short A Fatal Brain Stroke in Patient with Advanced Breast Cancer Treated with Bevacizumab: A Case Report
title_sort fatal brain stroke in patient with advanced breast cancer treated with bevacizumab: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649753/
https://www.ncbi.nlm.nih.gov/pubmed/29147218
http://dx.doi.org/10.4021/wjon265w
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