Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases

The optimal second-line chemotherapeutic regimen for thymic carcinoma remains uncertain and predictive factors for the response have not been identified. We encountered two cases of relapsed thymic carcinoma with recurrence 1.5 and 8 years after initial response to cisplatin/doxorubicin/vincristine/...

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Autores principales: Nomura, Yayoi, Koizumi, Tomonobu, Kitaguchi, Akihiro, Horiuchi, Toshimichi, Kanda, Shintarou, Yamamoto, Hiroshi, Hanaoka, Masayuki, Kubo, Keishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649833/
https://www.ncbi.nlm.nih.gov/pubmed/29147275
http://dx.doi.org/10.4021/wjon435w
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author Nomura, Yayoi
Koizumi, Tomonobu
Kitaguchi, Akihiro
Horiuchi, Toshimichi
Kanda, Shintarou
Yamamoto, Hiroshi
Hanaoka, Masayuki
Kubo, Keishi
author_facet Nomura, Yayoi
Koizumi, Tomonobu
Kitaguchi, Akihiro
Horiuchi, Toshimichi
Kanda, Shintarou
Yamamoto, Hiroshi
Hanaoka, Masayuki
Kubo, Keishi
author_sort Nomura, Yayoi
collection PubMed
description The optimal second-line chemotherapeutic regimen for thymic carcinoma remains uncertain and predictive factors for the response have not been identified. We encountered two cases of relapsed thymic carcinoma with recurrence 1.5 and 8 years after initial response to cisplatin/doxorubicin/vincristine/cyclophosphamide (ADOC) chemotherapy. Both cases were successfully retreated with ADOC. Our observations suggest that relapsed thymic carcinoma occurring a long treatment-free time from the initial response may be sensitive to the previous chemotherapy. We described two cases of relapsed thymic carcinoma successfully retreated with ADOC chemotherapy. Both patients had partial response to initial ADOC and long disease free times.
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spelling pubmed-56498332017-11-16 Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases Nomura, Yayoi Koizumi, Tomonobu Kitaguchi, Akihiro Horiuchi, Toshimichi Kanda, Shintarou Yamamoto, Hiroshi Hanaoka, Masayuki Kubo, Keishi World J Oncol Case Report The optimal second-line chemotherapeutic regimen for thymic carcinoma remains uncertain and predictive factors for the response have not been identified. We encountered two cases of relapsed thymic carcinoma with recurrence 1.5 and 8 years after initial response to cisplatin/doxorubicin/vincristine/cyclophosphamide (ADOC) chemotherapy. Both cases were successfully retreated with ADOC. Our observations suggest that relapsed thymic carcinoma occurring a long treatment-free time from the initial response may be sensitive to the previous chemotherapy. We described two cases of relapsed thymic carcinoma successfully retreated with ADOC chemotherapy. Both patients had partial response to initial ADOC and long disease free times. Elmer Press 2012-02 2012-02-19 /pmc/articles/PMC5649833/ /pubmed/29147275 http://dx.doi.org/10.4021/wjon435w Text en Copyright 2012, Nomura et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nomura, Yayoi
Koizumi, Tomonobu
Kitaguchi, Akihiro
Horiuchi, Toshimichi
Kanda, Shintarou
Yamamoto, Hiroshi
Hanaoka, Masayuki
Kubo, Keishi
Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title_full Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title_fullStr Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title_full_unstemmed Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title_short Successful Retreatment With ADOC Chemotherapy in Relapsed Thymic Carcinoma: Experiences in Two Cases
title_sort successful retreatment with adoc chemotherapy in relapsed thymic carcinoma: experiences in two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649833/
https://www.ncbi.nlm.nih.gov/pubmed/29147275
http://dx.doi.org/10.4021/wjon435w
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