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Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis

BACKGROUND: Although anticoagulation therapy is commonly used in the prostate cancer population, there are only a few studies about the correlation between radiation proctitis and anticoagulation therapy. The purpose of the present study was to determine whether low-dose aspirin increases the severi...

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Autores principales: Doi, Hiroshi, Kamikonya, Norihiko, Takada, Yasuhiro, Niwa, Yasue, Fujiwara, Masayuki, Tsuboi, Keita, Miura, Hideharu, Inoue, Hiroyuki, Tanooka, Masao, Nakamura, Takeshi, Shikata, Toshiyuki, Kimura, Takeshi, Tsujimura, Tohru, Hirota, Shozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649840/
https://www.ncbi.nlm.nih.gov/pubmed/29147301
http://dx.doi.org/10.4021/wjon559w
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author Doi, Hiroshi
Kamikonya, Norihiko
Takada, Yasuhiro
Niwa, Yasue
Fujiwara, Masayuki
Tsuboi, Keita
Miura, Hideharu
Inoue, Hiroyuki
Tanooka, Masao
Nakamura, Takeshi
Shikata, Toshiyuki
Kimura, Takeshi
Tsujimura, Tohru
Hirota, Shozo
author_facet Doi, Hiroshi
Kamikonya, Norihiko
Takada, Yasuhiro
Niwa, Yasue
Fujiwara, Masayuki
Tsuboi, Keita
Miura, Hideharu
Inoue, Hiroyuki
Tanooka, Masao
Nakamura, Takeshi
Shikata, Toshiyuki
Kimura, Takeshi
Tsujimura, Tohru
Hirota, Shozo
author_sort Doi, Hiroshi
collection PubMed
description BACKGROUND: Although anticoagulation therapy is commonly used in the prostate cancer population, there are only a few studies about the correlation between radiation proctitis and anticoagulation therapy. The purpose of the present study was to determine whether low-dose aspirin increases the severity of acute radiation proctitis in an experimental animal model. METHODS: Wistar rats were used in the present study. The rats were administered either aspirin at doses of 5, 10, and 20 mg/kg, or saline, daily before and after irradiation. The rats were irradiated to the rectum as a single fraction of 25 Gy. The rectal mucosal changes of each rat were evaluated macroscopically and pathologically on the tenth day following irradiation. The findings of proctitis were graded from 0 to 4, and then were compared with regard to the status. RESULTS: No apparent correlations were observed between the administration of aspirin and the severity of radiation proctitis in the macroscopic findings and in the morphological mucosal damage in the pathological examination. The proportion of rats with a severe degree of mucosal inflammation was 90.0%, 100.0%, 16.7% and 100.0% at 5 mg/kg, 10 mg/kg, and 20 mg/kg of aspirin, or saline, respectively. The rats receiving aspirin at the dose of 20 mg/kg showed significantly milder inflammation than the other groups (P < 0.05). CONCLUSIONS: In the present study, low-dose aspirin did not increase the severity of acute radiation proctitis. In addition, aspirin might decrease the severity of radiation-induced mucosal inflammation in the rectum.
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spelling pubmed-56498402017-11-16 Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis Doi, Hiroshi Kamikonya, Norihiko Takada, Yasuhiro Niwa, Yasue Fujiwara, Masayuki Tsuboi, Keita Miura, Hideharu Inoue, Hiroyuki Tanooka, Masao Nakamura, Takeshi Shikata, Toshiyuki Kimura, Takeshi Tsujimura, Tohru Hirota, Shozo World J Oncol Original Article BACKGROUND: Although anticoagulation therapy is commonly used in the prostate cancer population, there are only a few studies about the correlation between radiation proctitis and anticoagulation therapy. The purpose of the present study was to determine whether low-dose aspirin increases the severity of acute radiation proctitis in an experimental animal model. METHODS: Wistar rats were used in the present study. The rats were administered either aspirin at doses of 5, 10, and 20 mg/kg, or saline, daily before and after irradiation. The rats were irradiated to the rectum as a single fraction of 25 Gy. The rectal mucosal changes of each rat were evaluated macroscopically and pathologically on the tenth day following irradiation. The findings of proctitis were graded from 0 to 4, and then were compared with regard to the status. RESULTS: No apparent correlations were observed between the administration of aspirin and the severity of radiation proctitis in the macroscopic findings and in the morphological mucosal damage in the pathological examination. The proportion of rats with a severe degree of mucosal inflammation was 90.0%, 100.0%, 16.7% and 100.0% at 5 mg/kg, 10 mg/kg, and 20 mg/kg of aspirin, or saline, respectively. The rats receiving aspirin at the dose of 20 mg/kg showed significantly milder inflammation than the other groups (P < 0.05). CONCLUSIONS: In the present study, low-dose aspirin did not increase the severity of acute radiation proctitis. In addition, aspirin might decrease the severity of radiation-induced mucosal inflammation in the rectum. Elmer Press 2012-08 2012-08-26 /pmc/articles/PMC5649840/ /pubmed/29147301 http://dx.doi.org/10.4021/wjon559w Text en Copyright 2012, Doi et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Doi, Hiroshi
Kamikonya, Norihiko
Takada, Yasuhiro
Niwa, Yasue
Fujiwara, Masayuki
Tsuboi, Keita
Miura, Hideharu
Inoue, Hiroyuki
Tanooka, Masao
Nakamura, Takeshi
Shikata, Toshiyuki
Kimura, Takeshi
Tsujimura, Tohru
Hirota, Shozo
Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title_full Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title_fullStr Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title_full_unstemmed Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title_short Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis
title_sort low-dose aspirin therapy does not increase the severity of acute radiation proctitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649840/
https://www.ncbi.nlm.nih.gov/pubmed/29147301
http://dx.doi.org/10.4021/wjon559w
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