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Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon

Carcinoid tumors are a histological subtype of well differentiated, low to intermediate grade, slow-growing neuroendocrine malignancies capable of secreting bioactive peptides, such as 5-hydroxytryptamine (5-HT, serotonin), chromogranin-A and chromogranin-C. Here we present a case of a duodenal carc...

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Autores principales: Gao, Limin, Lipka, Seth, Hurtado-Cordovi, Jorge, Avezbakiyev, Boris, Zuretti, Alejandro, Rizvon, Kaleem, Mustacchia, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649904/
https://www.ncbi.nlm.nih.gov/pubmed/29147314
http://dx.doi.org/10.4021/wjon554w
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author Gao, Limin
Lipka, Seth
Hurtado-Cordovi, Jorge
Avezbakiyev, Boris
Zuretti, Alejandro
Rizvon, Kaleem
Mustacchia, Paul
author_facet Gao, Limin
Lipka, Seth
Hurtado-Cordovi, Jorge
Avezbakiyev, Boris
Zuretti, Alejandro
Rizvon, Kaleem
Mustacchia, Paul
author_sort Gao, Limin
collection PubMed
description Carcinoid tumors are a histological subtype of well differentiated, low to intermediate grade, slow-growing neuroendocrine malignancies capable of secreting bioactive peptides, such as 5-hydroxytryptamine (5-HT, serotonin), chromogranin-A and chromogranin-C. Here we present a case of a duodenal carcinoid that simultaneously occurred with adenocarcinoma of the colon. A 59-year-old male with a past medical history of hepatitis C and hypertension presented complaining of worsening abdominal pain associated with 2 - 3 episodes per week of bright red blood per rectum for the past month. He also reported a 20 pounds weight loss in the last 6 months. Social history was significant for a 15 pack year history. Vitals on admission were within normal limits. Physical exam was significant for right upper quadrant tenderness without guarding, rebound, or organomegaly. Rectal exam revealed no blood or masses. Laboratory results showed iron deficiency anemia with hemoglobin of 9.6 K/mm(3). Esophagogastroduodenoscopy revealed a 4 mm duodenal polyp. Colonoscopy was terminated early secondary to a large circumferential obstructing mass found in the descending colon. Immunohistochemistry of the duodenal biopsy was positive for synaptophysin and chromogranin-A; consistent with the diagnosis of stage I carcinoid tumor. Biopsy results of the colonic mass showed a stage I well-differentiated adenocarcinoma. The patient underwent a left colectomy and partial duodenectomy; he remains in remission after 2 year of close follow up. When the diagnosis of small bowel carcinoid is made, further screening for other primary neoplasms should be sought to prevent potential late stage diagnosis of synchronous malignancies. This is crucial because patients’ demise usually result from the associate tumor and not the carcinoid component. Finally, we would like to raise clinician’s awareness regarding the incidence of this entity since some of the studies suggest that it is more common than it was previously thought.
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spelling pubmed-56499042017-11-16 Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon Gao, Limin Lipka, Seth Hurtado-Cordovi, Jorge Avezbakiyev, Boris Zuretti, Alejandro Rizvon, Kaleem Mustacchia, Paul World J Oncol Case Report Carcinoid tumors are a histological subtype of well differentiated, low to intermediate grade, slow-growing neuroendocrine malignancies capable of secreting bioactive peptides, such as 5-hydroxytryptamine (5-HT, serotonin), chromogranin-A and chromogranin-C. Here we present a case of a duodenal carcinoid that simultaneously occurred with adenocarcinoma of the colon. A 59-year-old male with a past medical history of hepatitis C and hypertension presented complaining of worsening abdominal pain associated with 2 - 3 episodes per week of bright red blood per rectum for the past month. He also reported a 20 pounds weight loss in the last 6 months. Social history was significant for a 15 pack year history. Vitals on admission were within normal limits. Physical exam was significant for right upper quadrant tenderness without guarding, rebound, or organomegaly. Rectal exam revealed no blood or masses. Laboratory results showed iron deficiency anemia with hemoglobin of 9.6 K/mm(3). Esophagogastroduodenoscopy revealed a 4 mm duodenal polyp. Colonoscopy was terminated early secondary to a large circumferential obstructing mass found in the descending colon. Immunohistochemistry of the duodenal biopsy was positive for synaptophysin and chromogranin-A; consistent with the diagnosis of stage I carcinoid tumor. Biopsy results of the colonic mass showed a stage I well-differentiated adenocarcinoma. The patient underwent a left colectomy and partial duodenectomy; he remains in remission after 2 year of close follow up. When the diagnosis of small bowel carcinoid is made, further screening for other primary neoplasms should be sought to prevent potential late stage diagnosis of synchronous malignancies. This is crucial because patients’ demise usually result from the associate tumor and not the carcinoid component. Finally, we would like to raise clinician’s awareness regarding the incidence of this entity since some of the studies suggest that it is more common than it was previously thought. Elmer Press 2012-10 2012-10-28 /pmc/articles/PMC5649904/ /pubmed/29147314 http://dx.doi.org/10.4021/wjon554w Text en Copyright 2012, Gao et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gao, Limin
Lipka, Seth
Hurtado-Cordovi, Jorge
Avezbakiyev, Boris
Zuretti, Alejandro
Rizvon, Kaleem
Mustacchia, Paul
Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title_full Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title_fullStr Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title_full_unstemmed Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title_short Synchronous Duodenal Carcinoid and Adenocarcinoma of the Colon
title_sort synchronous duodenal carcinoid and adenocarcinoma of the colon
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649904/
https://www.ncbi.nlm.nih.gov/pubmed/29147314
http://dx.doi.org/10.4021/wjon554w
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