Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report

A 96-year-old woman with a 5-year history of multiple myeloma was admitted to our hospital because of increasing fatigue and fever. Bone marrow plasma cell analysis showed t(11;14), del(13q), and del(17p13). Her condition deteriorated, and she developed plasmacytosis resembling plasma cell leukemia....

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Detalles Bibliográficos
Autores principales: Akuzawa, Nobuhiro, Hatori, Takashi, Imai, Kunihiko, Kitahara, Yonosuke, Sakurai, Shinji, Kurabayashi, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649927/
https://www.ncbi.nlm.nih.gov/pubmed/29147355
http://dx.doi.org/10.4021/wjon688w
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author Akuzawa, Nobuhiro
Hatori, Takashi
Imai, Kunihiko
Kitahara, Yonosuke
Sakurai, Shinji
Kurabayashi, Masahiko
author_facet Akuzawa, Nobuhiro
Hatori, Takashi
Imai, Kunihiko
Kitahara, Yonosuke
Sakurai, Shinji
Kurabayashi, Masahiko
author_sort Akuzawa, Nobuhiro
collection PubMed
description A 96-year-old woman with a 5-year history of multiple myeloma was admitted to our hospital because of increasing fatigue and fever. Bone marrow plasma cell analysis showed t(11;14), del(13q), and del(17p13). Her condition deteriorated, and she developed plasmacytosis resembling plasma cell leukemia. Chromosome analysis showed trisomy of chromosome 8 in the circulating plasma cells. The plasmacytosis resolved spontaneously without chemotherapy after about 5 weeks, and the trisomy became undetectable. The findings suggest that trisomy 8 might have contributed to the transient plasmacytosis, and that chromosome 8 carries genes associated with plasma cell proliferation, maturation, and apoptosis.
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spelling pubmed-56499272017-11-16 Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report Akuzawa, Nobuhiro Hatori, Takashi Imai, Kunihiko Kitahara, Yonosuke Sakurai, Shinji Kurabayashi, Masahiko World J Oncol Case Report A 96-year-old woman with a 5-year history of multiple myeloma was admitted to our hospital because of increasing fatigue and fever. Bone marrow plasma cell analysis showed t(11;14), del(13q), and del(17p13). Her condition deteriorated, and she developed plasmacytosis resembling plasma cell leukemia. Chromosome analysis showed trisomy of chromosome 8 in the circulating plasma cells. The plasmacytosis resolved spontaneously without chemotherapy after about 5 weeks, and the trisomy became undetectable. The findings suggest that trisomy 8 might have contributed to the transient plasmacytosis, and that chromosome 8 carries genes associated with plasma cell proliferation, maturation, and apoptosis. Elmer Press 2013-10 2013-09-27 /pmc/articles/PMC5649927/ /pubmed/29147355 http://dx.doi.org/10.4021/wjon688w Text en Copyright 2013, Akuzawa et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Akuzawa, Nobuhiro
Hatori, Takashi
Imai, Kunihiko
Kitahara, Yonosuke
Sakurai, Shinji
Kurabayashi, Masahiko
Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title_full Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title_fullStr Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title_full_unstemmed Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title_short Transient Plasmacytosis With Trisomy of Chromosome 8 in a Patient With Multiple Myeloma: A Case Report
title_sort transient plasmacytosis with trisomy of chromosome 8 in a patient with multiple myeloma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649927/
https://www.ncbi.nlm.nih.gov/pubmed/29147355
http://dx.doi.org/10.4021/wjon688w
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