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Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients

BACKGROUND: Ovarian cancer is the leading cause of death from gynaecological malignancies. Newer biological prognostic factors and predictors of response to therapy are needed. Our study was designed to evaluate the expression of p53, Bcl-2, Estrogen receptor (ER) and Progesterone receptor (PR) in o...

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Autores principales: Ayadi, Lobna, Chaabouni, Salma, Khabir, Abdelmajid, Amouri, Habib, Makni, Saloua, Guermazi, Mohamed, Frikha, Mounir, Boudawara, Tahya Sellami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649935/
https://www.ncbi.nlm.nih.gov/pubmed/29147191
http://dx.doi.org/10.4021/wjon2010.06.213w
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author Ayadi, Lobna
Chaabouni, Salma
Khabir, Abdelmajid
Amouri, Habib
Makni, Saloua
Guermazi, Mohamed
Frikha, Mounir
Boudawara, Tahya Sellami
author_facet Ayadi, Lobna
Chaabouni, Salma
Khabir, Abdelmajid
Amouri, Habib
Makni, Saloua
Guermazi, Mohamed
Frikha, Mounir
Boudawara, Tahya Sellami
author_sort Ayadi, Lobna
collection PubMed
description BACKGROUND: Ovarian cancer is the leading cause of death from gynaecological malignancies. Newer biological prognostic factors and predictors of response to therapy are needed. Our study was designed to evaluate the expression of p53, Bcl-2, Estrogen receptor (ER) and Progesterone receptor (PR) in ovarian carcinoma and to compare it with other prognostic parameters such as age, FIGO stage, size of residual tumor, histological type and grade. METHODS: This is a retrospective study conducted in the department of pathology at Sfax University Hospital. Confirmed 57 cases of ovarian carcinoma were reviewed in the period between January 1995 and December 2006. We used immunohistochemistry to evaluate the expression of p53, Bcl-2, ER and PR receptors and Chi-Square and Student test to correlate immunohistochemical findings with some prognostic parameters of ovarian carcinoma. RESULTS: The percentage of expression of p53, Bcl-2, ER and PR was 73,7; 47,4; 35,1 and 33,3 % respectively. p53 overexpression correlated with an advanced FIGO stage (p = 0,026) and presence of ascitis (p < 10(-4)). The expression of PR was associated with an early stage (FIGO I and II), a non serous histologic type and a low tumour grade (p = 0,045; 0,010 and 0,036 respectively). No correlation was found between Bcl-2 and ER and prognostic parameters. Survival analysis revealed that Bcl-2 status, FIGO stage, presence of ascites, peritoneal cytology, and residual disease were significant predictive factors of survival. CONCLUSION: p53 expression correlates with a worse prognosis in epithelial ovarian cancer, whereas Bcl-2 expression is related to a better outcome. For hormonal status, expression of PR is found to be an independent indicator of favourable prognosis. These results should be supported by more and larger studies.
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spelling pubmed-56499352017-11-16 Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients Ayadi, Lobna Chaabouni, Salma Khabir, Abdelmajid Amouri, Habib Makni, Saloua Guermazi, Mohamed Frikha, Mounir Boudawara, Tahya Sellami World J Oncol Original Article BACKGROUND: Ovarian cancer is the leading cause of death from gynaecological malignancies. Newer biological prognostic factors and predictors of response to therapy are needed. Our study was designed to evaluate the expression of p53, Bcl-2, Estrogen receptor (ER) and Progesterone receptor (PR) in ovarian carcinoma and to compare it with other prognostic parameters such as age, FIGO stage, size of residual tumor, histological type and grade. METHODS: This is a retrospective study conducted in the department of pathology at Sfax University Hospital. Confirmed 57 cases of ovarian carcinoma were reviewed in the period between January 1995 and December 2006. We used immunohistochemistry to evaluate the expression of p53, Bcl-2, ER and PR receptors and Chi-Square and Student test to correlate immunohistochemical findings with some prognostic parameters of ovarian carcinoma. RESULTS: The percentage of expression of p53, Bcl-2, ER and PR was 73,7; 47,4; 35,1 and 33,3 % respectively. p53 overexpression correlated with an advanced FIGO stage (p = 0,026) and presence of ascitis (p < 10(-4)). The expression of PR was associated with an early stage (FIGO I and II), a non serous histologic type and a low tumour grade (p = 0,045; 0,010 and 0,036 respectively). No correlation was found between Bcl-2 and ER and prognostic parameters. Survival analysis revealed that Bcl-2 status, FIGO stage, presence of ascites, peritoneal cytology, and residual disease were significant predictive factors of survival. CONCLUSION: p53 expression correlates with a worse prognosis in epithelial ovarian cancer, whereas Bcl-2 expression is related to a better outcome. For hormonal status, expression of PR is found to be an independent indicator of favourable prognosis. These results should be supported by more and larger studies. Elmer Press 2010-06 2010-05-19 /pmc/articles/PMC5649935/ /pubmed/29147191 http://dx.doi.org/10.4021/wjon2010.06.213w Text en Copyright 2010, Ayadi et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ayadi, Lobna
Chaabouni, Salma
Khabir, Abdelmajid
Amouri, Habib
Makni, Saloua
Guermazi, Mohamed
Frikha, Mounir
Boudawara, Tahya Sellami
Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title_full Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title_fullStr Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title_full_unstemmed Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title_short Correlation Between Immunohistochemical Biomarkers Expression and Prognosis of Ovarian Carcinomas in Tunisian Patients
title_sort correlation between immunohistochemical biomarkers expression and prognosis of ovarian carcinomas in tunisian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649935/
https://www.ncbi.nlm.nih.gov/pubmed/29147191
http://dx.doi.org/10.4021/wjon2010.06.213w
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