A placebo-controlled Bayesian dose finding design based on continuous reassessment method with application to stroke research

Traditional dose-finding designs do not require assignment of patients to a control group. Motivated by SHRINC (Safety of Pioglitazone for hematoma resolution in intracerebral hemorrhage), we developed a placebo-controlled dose-finding study to identify the maximum tolerated dose for pioglitazone in...

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Detalles Bibliográficos
Autores principales: Cai, Chunyan, Rahbar, Mohammad H., Hossain, Md Monir, Yuan, Ying, Gonzales, Nicole R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650116/
https://www.ncbi.nlm.nih.gov/pubmed/29062975
http://dx.doi.org/10.1016/j.conctc.2017.05.002

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