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Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia

OBJECTIVE: To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia. METHODS: Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34(+0) weeks of gestation (early-onset preeclampsia) and ≥ 3...

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Autores principales: Weber, Thomas Michael, Lackner, Helmut Karl, Roessler, Andreas, Papousek, Ilona, Kolovetsiou-Kreiner, Vassiliki, Lucovnik, Miha, Schmid-Zalaudek, Karin, Lang, Uwe, Moertl, Manfred Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650147/
https://www.ncbi.nlm.nih.gov/pubmed/29053723
http://dx.doi.org/10.1371/journal.pone.0186521
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author Weber, Thomas Michael
Lackner, Helmut Karl
Roessler, Andreas
Papousek, Ilona
Kolovetsiou-Kreiner, Vassiliki
Lucovnik, Miha
Schmid-Zalaudek, Karin
Lang, Uwe
Moertl, Manfred Georg
author_facet Weber, Thomas Michael
Lackner, Helmut Karl
Roessler, Andreas
Papousek, Ilona
Kolovetsiou-Kreiner, Vassiliki
Lucovnik, Miha
Schmid-Zalaudek, Karin
Lang, Uwe
Moertl, Manfred Georg
author_sort Weber, Thomas Michael
collection PubMed
description OBJECTIVE: To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia. METHODS: Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34(+0) weeks of gestation (early-onset preeclampsia) and ≥ 34(+0) weeks of gestation (late-onset preeclampsia). For each case in each of the preeclampsia subgroups, three „control”uncomplicated singleton pregnancies were matched by maternal age, height, and week of gestation. Blood pressure and heart rate were measured continuously for 30 minutes in each participant. Baroreceptor reflex sensitivity (assessed using sequence technique), time and frequency domain heart rate variability measures, as SDNN, RMSSD, LF(RRI), HF(RRI) and LF/HF(RRI) of R-R intervals, were compared between groups (p<0.05 significant). RESULTS: 24 women with preeclampsia (10 with early-onset and 14 with late-onset preeclampsia) and 72 controls were included in the study. SDNN, RMSSD and HF(RRI) were significantly higher in the late-onset preeclampsia group compared to gestational age matched controls (p = 0.033, p = 0.002 and p = 0.018, respectively). No significant differences in SDNN RMSSD and HF(RRI) between early-onset preeclampsia group and gestational age matched controls were observed (p = 0.304, p = 0.325 and p = 0.824, respectively). Similarly, baroreceptor reflex sensitivity was higher in late-onset preeclampsia compared to controls at ≥ 34 weeks (p = 0.037), but not different between early-onset preeclampsia compared to controls at < 34 weeks (p = 0.50). CONCLUSIONS: Heart rate variability and baroreceptor reflex sensitivity are increased in late- but not early-onset preeclampsia compared to healthy pregnancies. This indicates a better autonomic nervous system mediated adaptation to preeclampsia related cardiovascular changes in late-onset disease.
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spelling pubmed-56501472017-11-03 Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia Weber, Thomas Michael Lackner, Helmut Karl Roessler, Andreas Papousek, Ilona Kolovetsiou-Kreiner, Vassiliki Lucovnik, Miha Schmid-Zalaudek, Karin Lang, Uwe Moertl, Manfred Georg PLoS One Research Article OBJECTIVE: To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia. METHODS: Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34(+0) weeks of gestation (early-onset preeclampsia) and ≥ 34(+0) weeks of gestation (late-onset preeclampsia). For each case in each of the preeclampsia subgroups, three „control”uncomplicated singleton pregnancies were matched by maternal age, height, and week of gestation. Blood pressure and heart rate were measured continuously for 30 minutes in each participant. Baroreceptor reflex sensitivity (assessed using sequence technique), time and frequency domain heart rate variability measures, as SDNN, RMSSD, LF(RRI), HF(RRI) and LF/HF(RRI) of R-R intervals, were compared between groups (p<0.05 significant). RESULTS: 24 women with preeclampsia (10 with early-onset and 14 with late-onset preeclampsia) and 72 controls were included in the study. SDNN, RMSSD and HF(RRI) were significantly higher in the late-onset preeclampsia group compared to gestational age matched controls (p = 0.033, p = 0.002 and p = 0.018, respectively). No significant differences in SDNN RMSSD and HF(RRI) between early-onset preeclampsia group and gestational age matched controls were observed (p = 0.304, p = 0.325 and p = 0.824, respectively). Similarly, baroreceptor reflex sensitivity was higher in late-onset preeclampsia compared to controls at ≥ 34 weeks (p = 0.037), but not different between early-onset preeclampsia compared to controls at < 34 weeks (p = 0.50). CONCLUSIONS: Heart rate variability and baroreceptor reflex sensitivity are increased in late- but not early-onset preeclampsia compared to healthy pregnancies. This indicates a better autonomic nervous system mediated adaptation to preeclampsia related cardiovascular changes in late-onset disease. Public Library of Science 2017-10-20 /pmc/articles/PMC5650147/ /pubmed/29053723 http://dx.doi.org/10.1371/journal.pone.0186521 Text en © 2017 Weber et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Weber, Thomas Michael
Lackner, Helmut Karl
Roessler, Andreas
Papousek, Ilona
Kolovetsiou-Kreiner, Vassiliki
Lucovnik, Miha
Schmid-Zalaudek, Karin
Lang, Uwe
Moertl, Manfred Georg
Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title_full Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title_fullStr Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title_full_unstemmed Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title_short Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
title_sort heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650147/
https://www.ncbi.nlm.nih.gov/pubmed/29053723
http://dx.doi.org/10.1371/journal.pone.0186521
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