Impact of the structural integrity of the three-way junction of adenovirus VA(I) RNA on PKR inhibition

Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation factor 2α and attenuates viral protein transla...

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Detalles Bibliográficos
Autores principales: Dzananovic, Edis, Astha, Chojnowski, Grzegorz, Deo, Soumya, Booy, Evan P., Padilla-Meier, Pauline, McEleney, Kevin, Bujnicki, Janusz M., Patel, Trushar R., McKenna, Sean A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650172/
https://www.ncbi.nlm.nih.gov/pubmed/29053745
http://dx.doi.org/10.1371/journal.pone.0186849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650172/
https://www.ncbi.nlm.nih.gov/pubmed/29053745
http://dx.doi.org/10.1371/journal.pone.0186849

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