In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1(+/+) and aldh5a1(-/-) mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple paramet...

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Detalles Bibliográficos
Autores principales: Vogel, Kara R., Ainslie, Garrett R., Jansen, Erwin E., Salomons, Gajja S., Roullet, Jean-Baptiste, Gibson, K. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650182/
https://www.ncbi.nlm.nih.gov/pubmed/29053743
http://dx.doi.org/10.1371/journal.pone.0186919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650182/
https://www.ncbi.nlm.nih.gov/pubmed/29053743
http://dx.doi.org/10.1371/journal.pone.0186919

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