Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy

The neurotrophins (NTs) play a key role in neuronal survival and maintenance. The TRK (tropomyosin-related kinase) tyrosine kinase receptors (TRKA, TRKB, TRKC) are high affinity receptors for NTs. There is increasing data demonstrating an important role of the TRK family in cancer initiation and pro...

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Detalles Bibliográficos
Autores principales: Yang, Min, Pan, Zengkai, Huang, Kezhi, Büsche, Guntram, Feuerhake, Friedrich, Chaturvedi, Anuhar, Nie, Danian, Heuser, Michael, Thol, Felicitas, von Neuhoff, Nils, Ganser, Arnold, Li, Zhixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650308/
https://www.ncbi.nlm.nih.gov/pubmed/29088753
http://dx.doi.org/10.18632/oncotarget.18027

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