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MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma
Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Giv...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650313/ https://www.ncbi.nlm.nih.gov/pubmed/29088758 http://dx.doi.org/10.18632/oncotarget.17881 |
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author | Li, Wende Yang, Weining Liu, Yujiao Chen, Siyu Chin, Shanmin Qi, Xiaolong Zhao, Yingchao Liu, Hao Wang, Jiasheng Mei, Xueting Huang, Peigen Xu, Donghui |
author_facet | Li, Wende Yang, Weining Liu, Yujiao Chen, Siyu Chin, Shanmin Qi, Xiaolong Zhao, Yingchao Liu, Hao Wang, Jiasheng Mei, Xueting Huang, Peigen Xu, Donghui |
author_sort | Li, Wende |
collection | PubMed |
description | Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38. |
format | Online Article Text |
id | pubmed-5650313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56503132017-10-30 MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma Li, Wende Yang, Weining Liu, Yujiao Chen, Siyu Chin, Shanmin Qi, Xiaolong Zhao, Yingchao Liu, Hao Wang, Jiasheng Mei, Xueting Huang, Peigen Xu, Donghui Oncotarget Research Paper Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38. Impact Journals LLC 2017-05-16 /pmc/articles/PMC5650313/ /pubmed/29088758 http://dx.doi.org/10.18632/oncotarget.17881 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Li, Wende Yang, Weining Liu, Yujiao Chen, Siyu Chin, Shanmin Qi, Xiaolong Zhao, Yingchao Liu, Hao Wang, Jiasheng Mei, Xueting Huang, Peigen Xu, Donghui MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title | MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title_full | MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title_fullStr | MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title_full_unstemmed | MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title_short | MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma |
title_sort | microrna-378 enhances inhibitory effect of curcumin on glioblastoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650313/ https://www.ncbi.nlm.nih.gov/pubmed/29088758 http://dx.doi.org/10.18632/oncotarget.17881 |
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