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RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients

Scholars are striving to apply molecular biology involving long non-coding RNA (lncRNA) in the prognostication of papillary thyroid cancer (PTC). However, the clinical role of lncRNAs in the prognostic setting of PTC is still unclear. Herein, a comprehensive inquiry was performed to screen lncRNA ex...

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Autores principales: Luo, Yi-Huan, Liang, Liang, He, Rong-Quan, Wen, Dong-Yue, Deng, Guo-Fei, Yang, Hong, He, Yun, Ma, Wei, Cai, Xiao-Yong, Chen, Jun-Qiang, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650329/
https://www.ncbi.nlm.nih.gov/pubmed/29088774
http://dx.doi.org/10.18632/oncotarget.18274
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author Luo, Yi-Huan
Liang, Liang
He, Rong-Quan
Wen, Dong-Yue
Deng, Guo-Fei
Yang, Hong
He, Yun
Ma, Wei
Cai, Xiao-Yong
Chen, Jun-Qiang
Chen, Gang
author_facet Luo, Yi-Huan
Liang, Liang
He, Rong-Quan
Wen, Dong-Yue
Deng, Guo-Fei
Yang, Hong
He, Yun
Ma, Wei
Cai, Xiao-Yong
Chen, Jun-Qiang
Chen, Gang
author_sort Luo, Yi-Huan
collection PubMed
description Scholars are striving to apply molecular biology involving long non-coding RNA (lncRNA) in the prognostication of papillary thyroid cancer (PTC). However, the clinical role of lncRNAs in the prognostic setting of PTC is still unclear. Herein, a comprehensive inquiry was performed to screen lncRNA expression profiling with 507 PTC patients from The Cancer Genome Atlas RNA-sequencing datasets. A total of 734 lncRNAs were detected to be aberrantly expressed, among which three novel lncRNAs including AC079630.2, CRNDE and CTD-2171N6.1 were markedly related to the progression and survival of PTC. Furthermore, the aberrant expression of these lncRNAs could be verified by other cohorts from gene expression omnibus (GEO) as detected by microarrays. Next, we established a three-lncRNA signature and divided the PTC patients into two subgroups of high- and low-risk. Interestingly, patients with high-risk tended to gain obviously poorer outcome. Most importantly, this three-lncRNA signature was an independent biomarker to predict the patient survival of PTC. The accurate molecular roles of these three lncRNAs remains unclarified and warrants further characterization, but our current data propose that they might play pivotal roles in PTC tumorigenesis and more importantly, these novel lncRNAs are closely related to patients’ survival. These discoveries will have far-reaching consequences with respect to molecular prediction of PTC.
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spelling pubmed-56503292017-10-30 RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients Luo, Yi-Huan Liang, Liang He, Rong-Quan Wen, Dong-Yue Deng, Guo-Fei Yang, Hong He, Yun Ma, Wei Cai, Xiao-Yong Chen, Jun-Qiang Chen, Gang Oncotarget Research Paper Scholars are striving to apply molecular biology involving long non-coding RNA (lncRNA) in the prognostication of papillary thyroid cancer (PTC). However, the clinical role of lncRNAs in the prognostic setting of PTC is still unclear. Herein, a comprehensive inquiry was performed to screen lncRNA expression profiling with 507 PTC patients from The Cancer Genome Atlas RNA-sequencing datasets. A total of 734 lncRNAs were detected to be aberrantly expressed, among which three novel lncRNAs including AC079630.2, CRNDE and CTD-2171N6.1 were markedly related to the progression and survival of PTC. Furthermore, the aberrant expression of these lncRNAs could be verified by other cohorts from gene expression omnibus (GEO) as detected by microarrays. Next, we established a three-lncRNA signature and divided the PTC patients into two subgroups of high- and low-risk. Interestingly, patients with high-risk tended to gain obviously poorer outcome. Most importantly, this three-lncRNA signature was an independent biomarker to predict the patient survival of PTC. The accurate molecular roles of these three lncRNAs remains unclarified and warrants further characterization, but our current data propose that they might play pivotal roles in PTC tumorigenesis and more importantly, these novel lncRNAs are closely related to patients’ survival. These discoveries will have far-reaching consequences with respect to molecular prediction of PTC. Impact Journals LLC 2017-05-26 /pmc/articles/PMC5650329/ /pubmed/29088774 http://dx.doi.org/10.18632/oncotarget.18274 Text en Copyright: © 2017 Luo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Luo, Yi-Huan
Liang, Liang
He, Rong-Quan
Wen, Dong-Yue
Deng, Guo-Fei
Yang, Hong
He, Yun
Ma, Wei
Cai, Xiao-Yong
Chen, Jun-Qiang
Chen, Gang
RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title_full RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title_fullStr RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title_full_unstemmed RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title_short RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients
title_sort rna-sequencing investigation identifies an effective risk score generated by three novel lncrnas for the survival of papillary thyroid cancer patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650329/
https://www.ncbi.nlm.nih.gov/pubmed/29088774
http://dx.doi.org/10.18632/oncotarget.18274
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