A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis

NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are increasingly recognized as a key factor in inflammation and extracellular matrix accumulation in diabetic kidney disease. APX-115 (3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol HCl) is a novel orally active pan-Nox inhibitor. The...

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Detalles Bibliográficos
Autores principales: Kwon, Guideock, Uddin, Md Jamal, Lee, Gayoung, Jiang, Songling, Cho, Ahreum, Lee, Jung Hwa, Lee, Sae Rom, Bae, Yun Soo, Moon, Sung Hwan, Lee, Soo Jin, Cha, Dae Ryong, Ha, Hunjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650335/
https://www.ncbi.nlm.nih.gov/pubmed/29088780
http://dx.doi.org/10.18632/oncotarget.18540

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