A peptidomimetic with a chiral switch is an inhibitor of epidermal growth factor receptor heterodimerization

Among different types of EGFR dimers, EGFR-HER2 and HER2-HER3 are well known in different types of cancers. Targeting dimerization of EGFR will have a significant impact on cancer therapies. A symmetric peptidomimetic was designed to inhibit the protein-protein interaction of EGFR. The peptidomimeti...

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Detalles Bibliográficos
Autores principales: Kanthala, Shanthi P., Liu, Yong-Yu, Singh, Sitanshu, Sable, Rushikesh, Pallerla, Sandeep, Jois, Seetharama D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650337/
https://www.ncbi.nlm.nih.gov/pubmed/29088782
http://dx.doi.org/10.18632/oncotarget.19013

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