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Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival

To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide polymorphisms in PDGF pathway with melanoma-specific survival in 858 CM patients of...

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Autores principales: Li, Hong, Wang, Yanru, Liu, Hongliang, Shi, Qiong, Li, Hongyu, Wu, Wenting, Zhu, Dakai, Amos, Christopher I., Fang, Shenying, Lee, Jeffrey E., Li, Yi, Han, Jiali, Wei, Qingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650365/
https://www.ncbi.nlm.nih.gov/pubmed/29088810
http://dx.doi.org/10.18632/oncotarget.20245
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author Li, Hong
Wang, Yanru
Liu, Hongliang
Shi, Qiong
Li, Hongyu
Wu, Wenting
Zhu, Dakai
Amos, Christopher I.
Fang, Shenying
Lee, Jeffrey E.
Li, Yi
Han, Jiali
Wei, Qingyi
author_facet Li, Hong
Wang, Yanru
Liu, Hongliang
Shi, Qiong
Li, Hongyu
Wu, Wenting
Zhu, Dakai
Amos, Christopher I.
Fang, Shenying
Lee, Jeffrey E.
Li, Yi
Han, Jiali
Wei, Qingyi
author_sort Li, Hong
collection PubMed
description To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide polymorphisms in PDGF pathway with melanoma-specific survival in 858 CM patients of M.D. Anderson Cancer Center (MDACC). Additional data of 409 cases from Harvard University were also included for further analysis. We identified 13 SNPs in four genes (COL6A3, NCK2, COL5A1 and PRKCD) with a nominal P < 0.05 and false discovery rate (FDR) < 0.2 in MDACC dataset. Based on linkage disequilibrium, functional prediction and minor allele frequency, a representative SNP in each gene was selected. In the meta-analysis using MDACC and Harvard datasets, there were two SNPs associated with poor survival of CM patients: rs6707820 C>T in NCK2 (HR = 1.87, 95% CI = 1.35-2.59, P(meta) = 1.53E-5); and rs2306574 T>C in PRKCD (HR = 1.73, 95% CI = 1.33-2.24, P(meta) = 4.56E-6). Moreover, CM patients in MDACC with combined risk genotypes of these two loci had markedly poorer survival (HR = 2.47, 95% CI = 1.58-3.84, P < 0.001). Genetic variants of rs6707820 C>T in NCK2 and rs2306574 T>C in PRKCD of the PDGF signaling pathway may be biomarkers for melanoma survival.
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spelling pubmed-56503652017-10-30 Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival Li, Hong Wang, Yanru Liu, Hongliang Shi, Qiong Li, Hongyu Wu, Wenting Zhu, Dakai Amos, Christopher I. Fang, Shenying Lee, Jeffrey E. Li, Yi Han, Jiali Wei, Qingyi Oncotarget Research Paper To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide polymorphisms in PDGF pathway with melanoma-specific survival in 858 CM patients of M.D. Anderson Cancer Center (MDACC). Additional data of 409 cases from Harvard University were also included for further analysis. We identified 13 SNPs in four genes (COL6A3, NCK2, COL5A1 and PRKCD) with a nominal P < 0.05 and false discovery rate (FDR) < 0.2 in MDACC dataset. Based on linkage disequilibrium, functional prediction and minor allele frequency, a representative SNP in each gene was selected. In the meta-analysis using MDACC and Harvard datasets, there were two SNPs associated with poor survival of CM patients: rs6707820 C>T in NCK2 (HR = 1.87, 95% CI = 1.35-2.59, P(meta) = 1.53E-5); and rs2306574 T>C in PRKCD (HR = 1.73, 95% CI = 1.33-2.24, P(meta) = 4.56E-6). Moreover, CM patients in MDACC with combined risk genotypes of these two loci had markedly poorer survival (HR = 2.47, 95% CI = 1.58-3.84, P < 0.001). Genetic variants of rs6707820 C>T in NCK2 and rs2306574 T>C in PRKCD of the PDGF signaling pathway may be biomarkers for melanoma survival. Impact Journals LLC 2017-08-14 /pmc/articles/PMC5650365/ /pubmed/29088810 http://dx.doi.org/10.18632/oncotarget.20245 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Hong
Wang, Yanru
Liu, Hongliang
Shi, Qiong
Li, Hongyu
Wu, Wenting
Zhu, Dakai
Amos, Christopher I.
Fang, Shenying
Lee, Jeffrey E.
Li, Yi
Han, Jiali
Wei, Qingyi
Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title_full Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title_fullStr Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title_full_unstemmed Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title_short Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival
title_sort genetic variants of pdgf signaling pathway genes predict cutaneous melanoma survival
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650365/
https://www.ncbi.nlm.nih.gov/pubmed/29088810
http://dx.doi.org/10.18632/oncotarget.20245
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