Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells

Regular use of aspirin can reduce cancer incidence, recurrence, metastasis and cancer-related mortality. Aspirin suppresses proliferation and induces apoptosis and autophagy in colorectal cancer cells, but the precise mechanism is not clear. In this study, we demonstrated that aspirin induced autoph...

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Autores principales: Sun, Ting, Ming, Liang, Yan, Yunmeng, Zhang, Yan, Xue, Haikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650378/
https://www.ncbi.nlm.nih.gov/pubmed/29088823
http://dx.doi.org/10.18632/oncotarget.20367
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author Sun, Ting
Ming, Liang
Yan, Yunmeng
Zhang, Yan
Xue, Haikuo
author_facet Sun, Ting
Ming, Liang
Yan, Yunmeng
Zhang, Yan
Xue, Haikuo
author_sort Sun, Ting
collection PubMed
description Regular use of aspirin can reduce cancer incidence, recurrence, metastasis and cancer-related mortality. Aspirin suppresses proliferation and induces apoptosis and autophagy in colorectal cancer cells, but the precise mechanism is not clear. In this study, we demonstrated that aspirin induced autophagosome formation in colorectal cancer cells, but autophagic degradation was blocked through aspirin-mediated Beclin 1 acetylation. Blocked autophagic degradation weakened aspirin-induced cell death. Collectively, our findings indicate the dual roles of aspirin on autophagy, and demonstrate a new mechanism by which Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells.
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spelling pubmed-56503782017-10-30 Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells Sun, Ting Ming, Liang Yan, Yunmeng Zhang, Yan Xue, Haikuo Oncotarget Research Paper Regular use of aspirin can reduce cancer incidence, recurrence, metastasis and cancer-related mortality. Aspirin suppresses proliferation and induces apoptosis and autophagy in colorectal cancer cells, but the precise mechanism is not clear. In this study, we demonstrated that aspirin induced autophagosome formation in colorectal cancer cells, but autophagic degradation was blocked through aspirin-mediated Beclin 1 acetylation. Blocked autophagic degradation weakened aspirin-induced cell death. Collectively, our findings indicate the dual roles of aspirin on autophagy, and demonstrate a new mechanism by which Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. Impact Journals LLC 2017-08-19 /pmc/articles/PMC5650378/ /pubmed/29088823 http://dx.doi.org/10.18632/oncotarget.20367 Text en Copyright: © 2017 Sun et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Sun, Ting
Ming, Liang
Yan, Yunmeng
Zhang, Yan
Xue, Haikuo
Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title_full Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title_fullStr Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title_full_unstemmed Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title_short Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
title_sort beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650378/
https://www.ncbi.nlm.nih.gov/pubmed/29088823
http://dx.doi.org/10.18632/oncotarget.20367
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AT yanyunmeng beclin1acetylationimpairstheanticancereffectofaspirinincolorectalcancercells
AT zhangyan beclin1acetylationimpairstheanticancereffectofaspirinincolorectalcancercells
AT xuehaikuo beclin1acetylationimpairstheanticancereffectofaspirinincolorectalcancercells

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