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The association between obesity related adipokines and risk of breast cancer: a meta-analysis

The risk of breast cancer is significantly increased among obese women as the deleterious adipokines can be over secreted and beneficial adipokines can be hyposecreted. We aim to evaluate the association between obesity-associated adipokines and breast cancer. We searched PubMed, EMBASE, Web of Scie...

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Autores principales: Gui, Yu, Pan, Qinwen, Chen, Xianchun, Xu, Shuman, Luo, Xiangdong, Chen, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650429/
https://www.ncbi.nlm.nih.gov/pubmed/29088874
http://dx.doi.org/10.18632/oncotarget.17853
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author Gui, Yu
Pan, Qinwen
Chen, Xianchun
Xu, Shuman
Luo, Xiangdong
Chen, Li
author_facet Gui, Yu
Pan, Qinwen
Chen, Xianchun
Xu, Shuman
Luo, Xiangdong
Chen, Li
author_sort Gui, Yu
collection PubMed
description The risk of breast cancer is significantly increased among obese women as the deleterious adipokines can be over secreted and beneficial adipokines can be hyposecreted. We aim to evaluate the association between obesity-associated adipokines and breast cancer. We searched PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature (CBM) databases for studies reporting association of obesity related adipokines with breast cancer published before Sept. 15, 2015. Initially, 26783 publications were identified, and later, 119 articles were selected for further meta-analysis. Out of these 119 studies, twenty-six studies had reported adipokine levels among obese and non-obese healthy subjects and ninety-three studies had reported adipokine levels among patients with breast cancer. The subjects with BMI >25 kg/m2 had significantly lower adiponectin levels and higher leptin and tumor necrosis factor-α (TNF-α) levels than those with BMI <25 kg/m2. Decreased concentrations of adiponectin, and increased concentrations of leptin, IL-6, IL-8, TNF-α, resistin and visfatin were significantly associated with risk of breast cancer. Adipokine levels were strongly associated with breast cancer among Asian women as compared to non-Asian women. Our results might explain the relationship of obesity, adipokine levels and risk of breast cancer, especially in Asian women.
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spelling pubmed-56504292017-10-30 The association between obesity related adipokines and risk of breast cancer: a meta-analysis Gui, Yu Pan, Qinwen Chen, Xianchun Xu, Shuman Luo, Xiangdong Chen, Li Oncotarget Meta-Analysis The risk of breast cancer is significantly increased among obese women as the deleterious adipokines can be over secreted and beneficial adipokines can be hyposecreted. We aim to evaluate the association between obesity-associated adipokines and breast cancer. We searched PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature (CBM) databases for studies reporting association of obesity related adipokines with breast cancer published before Sept. 15, 2015. Initially, 26783 publications were identified, and later, 119 articles were selected for further meta-analysis. Out of these 119 studies, twenty-six studies had reported adipokine levels among obese and non-obese healthy subjects and ninety-three studies had reported adipokine levels among patients with breast cancer. The subjects with BMI >25 kg/m2 had significantly lower adiponectin levels and higher leptin and tumor necrosis factor-α (TNF-α) levels than those with BMI <25 kg/m2. Decreased concentrations of adiponectin, and increased concentrations of leptin, IL-6, IL-8, TNF-α, resistin and visfatin were significantly associated with risk of breast cancer. Adipokine levels were strongly associated with breast cancer among Asian women as compared to non-Asian women. Our results might explain the relationship of obesity, adipokine levels and risk of breast cancer, especially in Asian women. Impact Journals LLC 2017-05-13 /pmc/articles/PMC5650429/ /pubmed/29088874 http://dx.doi.org/10.18632/oncotarget.17853 Text en Copyright: © 2017 Gui et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Gui, Yu
Pan, Qinwen
Chen, Xianchun
Xu, Shuman
Luo, Xiangdong
Chen, Li
The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title_full The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title_fullStr The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title_full_unstemmed The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title_short The association between obesity related adipokines and risk of breast cancer: a meta-analysis
title_sort association between obesity related adipokines and risk of breast cancer: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650429/
https://www.ncbi.nlm.nih.gov/pubmed/29088874
http://dx.doi.org/10.18632/oncotarget.17853
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