Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, h...

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Autores principales: Zou, Yuanyuan, Zhang, Xi, Zhang, Jingyi, Ji, Xiangning, Liu, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Meta-Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650437/
https://www.ncbi.nlm.nih.gov/pubmed/29088882
http://dx.doi.org/10.18632/oncotarget.20636
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author Zou, Yuanyuan
Zhang, Xi
Zhang, Jingyi
Ji, Xiangning
Liu, Yuqing
author_facet Zou, Yuanyuan
Zhang, Xi
Zhang, Jingyi
Ji, Xiangning
Liu, Yuqing
author_sort Zou, Yuanyuan
collection PubMed
description We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.
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spelling pubmed-56504372017-10-30 Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis Zou, Yuanyuan Zhang, Xi Zhang, Jingyi Ji, Xiangning Liu, Yuqing Oncotarget Meta-Analysis We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population. Impact Journals LLC 2017-09-04 /pmc/articles/PMC5650437/ /pubmed/29088882 http://dx.doi.org/10.18632/oncotarget.20636 Text en Copyright: © 2017 Zou et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Zou, Yuanyuan
Zhang, Xi
Zhang, Jingyi
Ji, Xiangning
Liu, Yuqing
Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title_full Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title_fullStr Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title_full_unstemmed Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title_short Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis
title_sort factor v g1691a is associated with an increased risk of retinal vein occlusion: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650437/
https://www.ncbi.nlm.nih.gov/pubmed/29088882
http://dx.doi.org/10.18632/oncotarget.20636
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