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Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

The unfolded protein response (UPR) monitors and adjusts the protein folding capacity of the endoplasmic reticulum (ER). In S. pombe, the ER membrane-resident kinase/endoribonuclease Ire1 utilizes a mechanism of selective degradation of ER-bound mRNAs (RIDD) to maintain homeostasis. We used a geneti...

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Detalles Bibliográficos
Autores principales:	Guydosh, Nicholas R, Kimmig, Philipp, Walter, Peter, Green, Rachel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650469/ https://www.ncbi.nlm.nih.gov/pubmed/28945192 http://dx.doi.org/10.7554/eLife.29216

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