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Removal of inhibition uncovers latent movement potential during preparation

The motor system prepares for movements well in advance of their execution. In the gaze control system, the dynamics of preparatory neural activity have been well described by stochastic accumulation-to-threshold models. However, it is unclear whether this activity has features indicative of a hidde...

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Detalles Bibliográficos
Autores principales: Jagadisan, Uday K, Gandhi, Neeraj J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650474/
https://www.ncbi.nlm.nih.gov/pubmed/28891467
http://dx.doi.org/10.7554/eLife.29648
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author Jagadisan, Uday K
Gandhi, Neeraj J
author_facet Jagadisan, Uday K
Gandhi, Neeraj J
author_sort Jagadisan, Uday K
collection PubMed
description The motor system prepares for movements well in advance of their execution. In the gaze control system, the dynamics of preparatory neural activity have been well described by stochastic accumulation-to-threshold models. However, it is unclear whether this activity has features indicative of a hidden movement command. We explicitly tested whether preparatory neural activity in premotor neurons of the primate superior colliculus has ‘motor potential’. We removed downstream inhibition on the saccadic system using the trigeminal blink reflex, triggering saccades at earlier-than-normal latencies. Accumulating low-frequency activity was predictive of eye movement dynamics tens of milliseconds in advance of the actual saccade, indicating the presence of a latent movement command. We also show that reaching a fixed threshold level is not a necessary condition for movement initiation. The results bring into question extant models of saccade generation and support the possibility of a concurrent representation for movement preparation and generation.
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spelling pubmed-56504742017-10-23 Removal of inhibition uncovers latent movement potential during preparation Jagadisan, Uday K Gandhi, Neeraj J eLife Neuroscience The motor system prepares for movements well in advance of their execution. In the gaze control system, the dynamics of preparatory neural activity have been well described by stochastic accumulation-to-threshold models. However, it is unclear whether this activity has features indicative of a hidden movement command. We explicitly tested whether preparatory neural activity in premotor neurons of the primate superior colliculus has ‘motor potential’. We removed downstream inhibition on the saccadic system using the trigeminal blink reflex, triggering saccades at earlier-than-normal latencies. Accumulating low-frequency activity was predictive of eye movement dynamics tens of milliseconds in advance of the actual saccade, indicating the presence of a latent movement command. We also show that reaching a fixed threshold level is not a necessary condition for movement initiation. The results bring into question extant models of saccade generation and support the possibility of a concurrent representation for movement preparation and generation. eLife Sciences Publications, Ltd 2017-09-11 /pmc/articles/PMC5650474/ /pubmed/28891467 http://dx.doi.org/10.7554/eLife.29648 Text en © 2017, Jagadisan et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Jagadisan, Uday K
Gandhi, Neeraj J
Removal of inhibition uncovers latent movement potential during preparation
title Removal of inhibition uncovers latent movement potential during preparation
title_full Removal of inhibition uncovers latent movement potential during preparation
title_fullStr Removal of inhibition uncovers latent movement potential during preparation
title_full_unstemmed Removal of inhibition uncovers latent movement potential during preparation
title_short Removal of inhibition uncovers latent movement potential during preparation
title_sort removal of inhibition uncovers latent movement potential during preparation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650474/
https://www.ncbi.nlm.nih.gov/pubmed/28891467
http://dx.doi.org/10.7554/eLife.29648
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