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Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp
BACKGROUND: Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease. OBJECTIVE: To clarify and extend the knowledge of underlying chan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650679/ https://www.ncbi.nlm.nih.gov/pubmed/29085775 http://dx.doi.org/10.1016/j.nicl.2017.10.001 |
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author | Mantel, Tobias Meindl, Tobias Li, Yong Jochim, Angela Gora-Stahlberg, Gina Kräenbring, Jona Berndt, Maria Dresel, Christian Haslinger, Bernhard |
author_facet | Mantel, Tobias Meindl, Tobias Li, Yong Jochim, Angela Gora-Stahlberg, Gina Kräenbring, Jona Berndt, Maria Dresel, Christian Haslinger, Bernhard |
author_sort | Mantel, Tobias |
collection | PubMed |
description | BACKGROUND: Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease. OBJECTIVE: To clarify and extend the knowledge of underlying changes by investigating functional connectivity (FC) in intrinsic connectivity networks with putative sensorimotor function at rest in an increased number of study subjects. METHODS: Resting-state functional magnetic resonance imaging with independent component analysis was performed in 26/27 writer's cramp patients/healthy controls, and FC within and between resting state networks with putative sensorimotor function was compared. Additionally, voxel-based morphometry was carried out on the subjects' structural images. RESULTS: Patients displayed increased left- and reduced right-hemispheric primary sensorimotor FC in the premotor-parietal network. Mostly bilaterally altered dorsal/ventral premotor FC, as well as altered parietal FC were observed within multiple sensorimotor networks and showed differing network-dependent directionality. Beyond within-network FC changes and reduced right cerebellar grey matter volume in the structural analysis, the positive between-network FC of the cerebellar network and the basal ganglia network was reduced. CONCLUSIONS: Abnormal resting-state FC in multiple networks with putative sensorimotor function may act as basis of preexisting observations made during task-related neuroimaging. Further, altered connectivity between the cerebellar and basal ganglia network underlines the important role of these structures in the disease. |
format | Online Article Text |
id | pubmed-5650679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56506792017-10-30 Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp Mantel, Tobias Meindl, Tobias Li, Yong Jochim, Angela Gora-Stahlberg, Gina Kräenbring, Jona Berndt, Maria Dresel, Christian Haslinger, Bernhard Neuroimage Clin Regular Article BACKGROUND: Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease. OBJECTIVE: To clarify and extend the knowledge of underlying changes by investigating functional connectivity (FC) in intrinsic connectivity networks with putative sensorimotor function at rest in an increased number of study subjects. METHODS: Resting-state functional magnetic resonance imaging with independent component analysis was performed in 26/27 writer's cramp patients/healthy controls, and FC within and between resting state networks with putative sensorimotor function was compared. Additionally, voxel-based morphometry was carried out on the subjects' structural images. RESULTS: Patients displayed increased left- and reduced right-hemispheric primary sensorimotor FC in the premotor-parietal network. Mostly bilaterally altered dorsal/ventral premotor FC, as well as altered parietal FC were observed within multiple sensorimotor networks and showed differing network-dependent directionality. Beyond within-network FC changes and reduced right cerebellar grey matter volume in the structural analysis, the positive between-network FC of the cerebellar network and the basal ganglia network was reduced. CONCLUSIONS: Abnormal resting-state FC in multiple networks with putative sensorimotor function may act as basis of preexisting observations made during task-related neuroimaging. Further, altered connectivity between the cerebellar and basal ganglia network underlines the important role of these structures in the disease. Elsevier 2017-10-14 /pmc/articles/PMC5650679/ /pubmed/29085775 http://dx.doi.org/10.1016/j.nicl.2017.10.001 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Mantel, Tobias Meindl, Tobias Li, Yong Jochim, Angela Gora-Stahlberg, Gina Kräenbring, Jona Berndt, Maria Dresel, Christian Haslinger, Bernhard Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title | Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title_full | Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title_fullStr | Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title_full_unstemmed | Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title_short | Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
title_sort | network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650679/ https://www.ncbi.nlm.nih.gov/pubmed/29085775 http://dx.doi.org/10.1016/j.nicl.2017.10.001 |
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