The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?

Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cel...

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Autores principales: Garcia-Rodriguez, Karen M., Goenka, Anu, Alonso-Rasgado, Maria T., Hernández-Pando, Rogelio, Bulfone-Paus, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650967/
https://www.ncbi.nlm.nih.gov/pubmed/29089945
http://dx.doi.org/10.3389/fimmu.2017.01290
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author Garcia-Rodriguez, Karen M.
Goenka, Anu
Alonso-Rasgado, Maria T.
Hernández-Pando, Rogelio
Bulfone-Paus, Silvia
author_facet Garcia-Rodriguez, Karen M.
Goenka, Anu
Alonso-Rasgado, Maria T.
Hernández-Pando, Rogelio
Bulfone-Paus, Silvia
author_sort Garcia-Rodriguez, Karen M.
collection PubMed
description Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.
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spelling pubmed-56509672017-10-31 The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk? Garcia-Rodriguez, Karen M. Goenka, Anu Alonso-Rasgado, Maria T. Hernández-Pando, Rogelio Bulfone-Paus, Silvia Front Immunol Immunology Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections. Frontiers Media S.A. 2017-10-17 /pmc/articles/PMC5650967/ /pubmed/29089945 http://dx.doi.org/10.3389/fimmu.2017.01290 Text en Copyright © 2017 Garcia-Rodriguez, Goenka, Alonso-Rasgado, Hernández-Pando and Bulfone-Paus. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Garcia-Rodriguez, Karen M.
Goenka, Anu
Alonso-Rasgado, Maria T.
Hernández-Pando, Rogelio
Bulfone-Paus, Silvia
The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title_full The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title_fullStr The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title_full_unstemmed The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title_short The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?
title_sort role of mast cells in tuberculosis: orchestrating innate immune crosstalk?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650967/
https://www.ncbi.nlm.nih.gov/pubmed/29089945
http://dx.doi.org/10.3389/fimmu.2017.01290
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