Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers

Background: Calcitonin gene-related peptide (CGRP) is pivotal in the pathophysiology of migraine headaches and represents a promising target for migraine treatment. The humanized monoclonal antibody galcanezumab (LY2951742) binds to CGRP and may be effective in migraine prophylaxis. Objectives: The...

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Detalles Bibliográficos
Autores principales: Monteith, David, Collins, Emily C., Vandermeulen, Corinne, Van Hecken, Anne, Raddad, Eyas, Scherer, Joel C., Grayzel, David, Schuetz, Thomas J., de Hoon, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651004/
https://www.ncbi.nlm.nih.gov/pubmed/29089894
http://dx.doi.org/10.3389/fphar.2017.00740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651004/
https://www.ncbi.nlm.nih.gov/pubmed/29089894
http://dx.doi.org/10.3389/fphar.2017.00740

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