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Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study
AIM: It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA(1c), blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651341/ https://www.ncbi.nlm.nih.gov/pubmed/29067252 http://dx.doi.org/10.1016/j.jcte.2017.01.003 |
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author | Olesen, Kasper Jensen, Troels Mygind Diaz, Lars Jorge Møller, Anne Cathrine Laustrup Willaing, Ingrid Lyssenko, Valeriya |
author_facet | Olesen, Kasper Jensen, Troels Mygind Diaz, Lars Jorge Møller, Anne Cathrine Laustrup Willaing, Ingrid Lyssenko, Valeriya |
author_sort | Olesen, Kasper |
collection | PubMed |
description | AIM: It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA(1c), blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. METHODS: Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers. RESULTS: Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA(1c). CONCLUSIONS: Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors. |
format | Online Article Text |
id | pubmed-5651341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56513412017-10-24 Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study Olesen, Kasper Jensen, Troels Mygind Diaz, Lars Jorge Møller, Anne Cathrine Laustrup Willaing, Ingrid Lyssenko, Valeriya J Clin Transl Endocrinol Research Paper AIM: It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA(1c), blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. METHODS: Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers. RESULTS: Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA(1c). CONCLUSIONS: Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors. Elsevier 2017-02-11 /pmc/articles/PMC5651341/ /pubmed/29067252 http://dx.doi.org/10.1016/j.jcte.2017.01.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Olesen, Kasper Jensen, Troels Mygind Diaz, Lars Jorge Møller, Anne Cathrine Laustrup Willaing, Ingrid Lyssenko, Valeriya Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title | Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title_full | Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title_fullStr | Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title_full_unstemmed | Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title_short | Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study |
title_sort | sense of coherence is associated with ldl-cholesterol in patients with type 1 diabetes – the prolong-steno study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651341/ https://www.ncbi.nlm.nih.gov/pubmed/29067252 http://dx.doi.org/10.1016/j.jcte.2017.01.003 |
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