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Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease

INTRODUCTION: ORM-12741 is a novel selective antagonist of alpha-2C adrenoceptors. This trial evaluated the safety and efficacy of ORM-12741 in patients with Alzheimer's disease (AD). METHODS: A randomized, double-blind, placebo-controlled, exploratory phase 2a trial was conducted in 100 subjec...

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Detalles Bibliográficos
Autores principales:	Rinne, Juha O., Wesnes, Keith, Cummings, Jeffrey L., Hakulinen, Pasi, Hallikainen, Merja, Hänninen, Jutta, Murphy, Michael, Riordan, Henry, Scheinin, Mika, Soininen, Hilkka, Rouru, Juha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651366/ https://www.ncbi.nlm.nih.gov/pubmed/29067315 http://dx.doi.org/10.1016/j.trci.2016.11.004

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