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Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-...

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Autores principales: Leeuwis, Anna E., Hooghiemstra, Astrid M., Amier, Raquel, Ferro, Doeschka A., Franken, Leonie, Nijveldt, Robin, Kuijer, Joost P.A., Bronzwaer, Anne-Sophie G.T., van Lieshout, Johannes J., Rietberg, Marc B., Veerbeek, Janne M., Huijsmans, Rosalie J., Backx, Frank J.G., Teunissen, Charlotte E., Bron, Esther E., Barkhof, Frederik, Prins, Niels D., Shahzad, Rahil, Niessen, Wiro J., de Roos, Albert, van Osch, Matthias J.P., van Rossum, Albert C., Biessels, Geert J., van der Flier, Wiesje M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651416/
https://www.ncbi.nlm.nih.gov/pubmed/29067325
http://dx.doi.org/10.1016/j.trci.2017.02.002
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author Leeuwis, Anna E.
Hooghiemstra, Astrid M.
Amier, Raquel
Ferro, Doeschka A.
Franken, Leonie
Nijveldt, Robin
Kuijer, Joost P.A.
Bronzwaer, Anne-Sophie G.T.
van Lieshout, Johannes J.
Rietberg, Marc B.
Veerbeek, Janne M.
Huijsmans, Rosalie J.
Backx, Frank J.G.
Teunissen, Charlotte E.
Bron, Esther E.
Barkhof, Frederik
Prins, Niels D.
Shahzad, Rahil
Niessen, Wiro J.
de Roos, Albert
van Osch, Matthias J.P.
van Rossum, Albert C.
Biessels, Geert J.
van der Flier, Wiesje M.
author_facet Leeuwis, Anna E.
Hooghiemstra, Astrid M.
Amier, Raquel
Ferro, Doeschka A.
Franken, Leonie
Nijveldt, Robin
Kuijer, Joost P.A.
Bronzwaer, Anne-Sophie G.T.
van Lieshout, Johannes J.
Rietberg, Marc B.
Veerbeek, Janne M.
Huijsmans, Rosalie J.
Backx, Frank J.G.
Teunissen, Charlotte E.
Bron, Esther E.
Barkhof, Frederik
Prins, Niels D.
Shahzad, Rahil
Niessen, Wiro J.
de Roos, Albert
van Osch, Matthias J.P.
van Rossum, Albert C.
Biessels, Geert J.
van der Flier, Wiesje M.
author_sort Leeuwis, Anna E.
collection PubMed
description There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.
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spelling pubmed-56514162017-10-24 Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment Leeuwis, Anna E. Hooghiemstra, Astrid M. Amier, Raquel Ferro, Doeschka A. Franken, Leonie Nijveldt, Robin Kuijer, Joost P.A. Bronzwaer, Anne-Sophie G.T. van Lieshout, Johannes J. Rietberg, Marc B. Veerbeek, Janne M. Huijsmans, Rosalie J. Backx, Frank J.G. Teunissen, Charlotte E. Bron, Esther E. Barkhof, Frederik Prins, Niels D. Shahzad, Rahil Niessen, Wiro J. de Roos, Albert van Osch, Matthias J.P. van Rossum, Albert C. Biessels, Geert J. van der Flier, Wiesje M. Alzheimers Dement (N Y) Featured Article There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status. Elsevier 2017-03-06 /pmc/articles/PMC5651416/ /pubmed/29067325 http://dx.doi.org/10.1016/j.trci.2017.02.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Featured Article
Leeuwis, Anna E.
Hooghiemstra, Astrid M.
Amier, Raquel
Ferro, Doeschka A.
Franken, Leonie
Nijveldt, Robin
Kuijer, Joost P.A.
Bronzwaer, Anne-Sophie G.T.
van Lieshout, Johannes J.
Rietberg, Marc B.
Veerbeek, Janne M.
Huijsmans, Rosalie J.
Backx, Frank J.G.
Teunissen, Charlotte E.
Bron, Esther E.
Barkhof, Frederik
Prins, Niels D.
Shahzad, Rahil
Niessen, Wiro J.
de Roos, Albert
van Osch, Matthias J.P.
van Rossum, Albert C.
Biessels, Geert J.
van der Flier, Wiesje M.
Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title_full Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title_fullStr Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title_full_unstemmed Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title_short Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
title_sort design of the excersion-vci study: the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
topic Featured Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651416/
https://www.ncbi.nlm.nih.gov/pubmed/29067325
http://dx.doi.org/10.1016/j.trci.2017.02.002
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