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Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651416/ https://www.ncbi.nlm.nih.gov/pubmed/29067325 http://dx.doi.org/10.1016/j.trci.2017.02.002 |
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author | Leeuwis, Anna E. Hooghiemstra, Astrid M. Amier, Raquel Ferro, Doeschka A. Franken, Leonie Nijveldt, Robin Kuijer, Joost P.A. Bronzwaer, Anne-Sophie G.T. van Lieshout, Johannes J. Rietberg, Marc B. Veerbeek, Janne M. Huijsmans, Rosalie J. Backx, Frank J.G. Teunissen, Charlotte E. Bron, Esther E. Barkhof, Frederik Prins, Niels D. Shahzad, Rahil Niessen, Wiro J. de Roos, Albert van Osch, Matthias J.P. van Rossum, Albert C. Biessels, Geert J. van der Flier, Wiesje M. |
author_facet | Leeuwis, Anna E. Hooghiemstra, Astrid M. Amier, Raquel Ferro, Doeschka A. Franken, Leonie Nijveldt, Robin Kuijer, Joost P.A. Bronzwaer, Anne-Sophie G.T. van Lieshout, Johannes J. Rietberg, Marc B. Veerbeek, Janne M. Huijsmans, Rosalie J. Backx, Frank J.G. Teunissen, Charlotte E. Bron, Esther E. Barkhof, Frederik Prins, Niels D. Shahzad, Rahil Niessen, Wiro J. de Roos, Albert van Osch, Matthias J.P. van Rossum, Albert C. Biessels, Geert J. van der Flier, Wiesje M. |
author_sort | Leeuwis, Anna E. |
collection | PubMed |
description | There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status. |
format | Online Article Text |
id | pubmed-5651416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56514162017-10-24 Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment Leeuwis, Anna E. Hooghiemstra, Astrid M. Amier, Raquel Ferro, Doeschka A. Franken, Leonie Nijveldt, Robin Kuijer, Joost P.A. Bronzwaer, Anne-Sophie G.T. van Lieshout, Johannes J. Rietberg, Marc B. Veerbeek, Janne M. Huijsmans, Rosalie J. Backx, Frank J.G. Teunissen, Charlotte E. Bron, Esther E. Barkhof, Frederik Prins, Niels D. Shahzad, Rahil Niessen, Wiro J. de Roos, Albert van Osch, Matthias J.P. van Rossum, Albert C. Biessels, Geert J. van der Flier, Wiesje M. Alzheimers Dement (N Y) Featured Article There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status. Elsevier 2017-03-06 /pmc/articles/PMC5651416/ /pubmed/29067325 http://dx.doi.org/10.1016/j.trci.2017.02.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Featured Article Leeuwis, Anna E. Hooghiemstra, Astrid M. Amier, Raquel Ferro, Doeschka A. Franken, Leonie Nijveldt, Robin Kuijer, Joost P.A. Bronzwaer, Anne-Sophie G.T. van Lieshout, Johannes J. Rietberg, Marc B. Veerbeek, Janne M. Huijsmans, Rosalie J. Backx, Frank J.G. Teunissen, Charlotte E. Bron, Esther E. Barkhof, Frederik Prins, Niels D. Shahzad, Rahil Niessen, Wiro J. de Roos, Albert van Osch, Matthias J.P. van Rossum, Albert C. Biessels, Geert J. van der Flier, Wiesje M. Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title | Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title_full | Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title_fullStr | Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title_full_unstemmed | Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title_short | Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
title_sort | design of the excersion-vci study: the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment |
topic | Featured Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651416/ https://www.ncbi.nlm.nih.gov/pubmed/29067325 http://dx.doi.org/10.1016/j.trci.2017.02.002 |
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