Cargando…

Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation

INTRODUCTION: Zinc finger-like protein that regulates apoptosis (Zfra) is a naturally occurring 31-amino-acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells. METHODS: Ten-month-old triple-transgenic (3×Tg) mice for Alzheimer&...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Ming-Hui, Shih, Yao-Hsiang, Lin, Sing-Ru, Chang, Jean-Yun, Lin, Yu-Hao, Sze, Chun-I, Kuo, Yu-Min, Chang, Nan-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651433/ https://www.ncbi.nlm.nih.gov/pubmed/29067327 http://dx.doi.org/10.1016/j.trci.2017.02.001

Ejemplares similares

Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration
por: Lin, Yu-Hao, et al.
Publicado: (2022)

WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis
por: Chang, J-Y, et al.
Publicado: (2015)

Zfra is a small wizard in the mitochondrial apoptosis
por: Dudekula, Subhan, et al.
Publicado: (2010)

NPT088 reduces both amyloid-β and tau pathologies in transgenic mice
por: Levenson, Jonathan M., et al.
Publicado: (2016)

Role of SH3GLB1 in the regulation of CD133 expression in GBM cells
por: Chien, Chia-Hung, et al.
Publicado: (2023)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
por: Chang, Jean-Yun, et al.
Publicado: (2015)

The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability
por: Zong, Min, et al.
Publicado: (2011)

Detection of Alzheimer's disease amyloid beta 1‐42, p‐tau, and t‐tau assays
por: van Harten, Argonde C., et al.
Publicado: (2021)

SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma
por: Chien, Chia-Hung, et al.
Publicado: (2022)

Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1
por: Zhang, Caiyun, et al.
Publicado: (2020)

Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo
por: Su, Wan-Pei, et al.
Publicado: (2020)

Zfra activates memory Hyal-2+ CD3− CD19− spleen cells to block cancer growth, stemness, and metastasis in vivo
por: Lee, Ming-Hui, et al.
Publicado: (2015)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Distinct effects of beta‐amyloid and tau on cortical thickness in cognitively healthy older adults
por: Harrison, Theresa M., et al.
Publicado: (2020)

Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
por: Lussier, Firoza Z., et al.
Publicado: (2020)

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
por: Cooper, J Mark, et al.
Publicado: (2014)

Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community‐based cohort study
por: Fani, Lana, et al.
Publicado: (2020)

Tau aggregation and its interplay with amyloid-β
por: Nisbet, Rebecca M., et al.
Publicado: (2014)

Small molecules to target tau amyloid aggregation
por: Manglano-Artuñedo, Zoe, et al.
Publicado: (2023)

Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum
por: Salvadó, Gemma, et al.
Publicado: (2021)

SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection
por: Fino, Kristin K., et al.
Publicado: (2017)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

Population analysis of the GLB1 gene in South Brazil
por: Baiotto, Cléia, et al.
Publicado: (2011)

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 Tau(RD)-DsRed SH-SY5Y Cells
por: Chiang, Ni-Ni, et al.
Publicado: (2021)

Amyloid-β-Derived Peptidomimetics Inhibits Tau Aggregation
por: Gorantla, Nalini V., et al.
Publicado: (2021)

Mitotic transformation of TRAMM/TrappC12
por: Milev, Miroslav P., et al.
Publicado: (2015)

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2019)

UB-311, a novel UBITh(®) amyloid β peptide vaccine for mild Alzheimer's disease
por: Wang, Chang Yi, et al.
Publicado: (2017)

TRAPPC9 Mediates the Interaction between p150(Glued) and COPII Vesicles at the Target Membrane
por: Zong, Min, et al.
Publicado: (2012)

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity
por: Rush, Travis, et al.
Publicado: (2019)

Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2021)

Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation
por: Mancini, Ross S., et al.
Publicado: (2018)

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
por: Ghisays, Valentina, et al.
Publicado: (2020)

Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease
por: Koppel, Jeremy, et al.
Publicado: (2016)

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model
por: Riedel, Gernot, et al.
Publicado: (2020)

Tau local structure shields an amyloid-forming motif and controls aggregation propensity
por: Chen, Dailu, et al.
Publicado: (2019)

trappc11 is required for protein glycosylation in zebrafish and humans
por: DeRossi, Charles, et al.
Publicado: (2016)

Trappc9 Deficiency Impairs the Plasticity of Stem Cells
por: Usman, Muhammad, et al.
Publicado: (2022)

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice
por: Clavaguera, Florence, et al.
Publicado: (2013)

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation
por: Shin, Woo Shik, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ugb6o53qfj87kafad1mjdl9tjs