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Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation

INTRODUCTION: Zinc finger-like protein that regulates apoptosis (Zfra) is a naturally occurring 31-amino-acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells. METHODS: Ten-month-old triple-transgenic (3×Tg) mice for Alzheimer&...

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Detalles Bibliográficos
Autores principales:	Lee, Ming-Hui, Shih, Yao-Hsiang, Lin, Sing-Ru, Chang, Jean-Yun, Lin, Yu-Hao, Sze, Chun-I, Kuo, Yu-Min, Chang, Nan-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651433/ https://www.ncbi.nlm.nih.gov/pubmed/29067327 http://dx.doi.org/10.1016/j.trci.2017.02.001

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