The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression

In this study, chemical modification of 2′-deoxyinosine (2′-dI) and D-/L-isothymidine (D-/L-isoT) was performed on AS1411. They could promote the nucleotide-protein interaction by changing the local conformation. Twenty modified sequences were obtained, FCL-I and FCL-II showed the most noticeable ac...

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Detalles Bibliográficos
Autores principales: Fan, Xinmeng, Sun, Lidan, Li, Kunfeng, Yang, Xiantao, Cai, Baobin, Zhang, Yanfen, Zhu, Yuejie, Ma, Yuan, Guan, Zhu, Wu, Yun, Zhang, Lihe, Yang, Zhenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651494/
https://www.ncbi.nlm.nih.gov/pubmed/29246300
http://dx.doi.org/10.1016/j.omtn.2017.09.010

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