Redox active metals and H(2)O(2) mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models()

Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20 mM pl...

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Detalles Bibliográficos
Autores principales: Schoenfeld, Joshua D., Sibenaller, Zita A., Mapuskar, Kranti A., Bradley, Megan D., Wagner, Brett A., Buettner, Garry R., Monga, Varun, Milhem, Mohammed, Spitz, Douglas R., Allen, Bryan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651553/
https://www.ncbi.nlm.nih.gov/pubmed/29069637
http://dx.doi.org/10.1016/j.redox.2017.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651553/
https://www.ncbi.nlm.nih.gov/pubmed/29069637
http://dx.doi.org/10.1016/j.redox.2017.09.012

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