Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Antisense oligonucleotide (ASO)-based drug development is gaining significant momentum following the recent FDA approval of Eteplirsen (an ASO based on phosphorodiamidate morpholino) and Spinraza (2′-O-methoxyethyl-phosphorothioate) in late 2016. Their attractiveness is mainly due to the backbone mo...

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Detalles Bibliográficos
Autores principales: Tailhades, Julien, Takizawa, Hotake, Gait, Michael J., Wellings, Don A., Wade, John D., Aoki, Yoshitsugu, Shabanpoor, Fazel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651559/
https://www.ncbi.nlm.nih.gov/pubmed/29094037
http://dx.doi.org/10.3389/fchem.2017.00081

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