Cargando…

Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

BACKGROUND: Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The objective of this study was to investigate the target attain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris K., Scharf, Christina, Maier, Barbara, Schmitt, Maximilian V., Hartung, Niklas, Huisinga, Wilhelm, Vogeser, Michael, Frey, Lorenz, Zander, Johannes, Kloft, Charlotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651591/ https://www.ncbi.nlm.nih.gov/pubmed/29058601 http://dx.doi.org/10.1186/s13054-017-1829-4

Ejemplares similares

Evaluation of the MeroRisk Calculator, A User-Friendly Tool to Predict the Risk of Meropenem Target Non-Attainment in Critically Ill Patients
por: Liebchen, Uwe, et al.
Publicado: (2021)

No clinically relevant removal of meropenem by cytokine adsorber CytoSorb(®) in critically ill patients with sepsis or septic shock
por: Liebchen, Uwe, et al.
Publicado: (2021)

Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy
por: Maier, Corinna, et al.
Publicado: (2020)

Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology
por: Maier, Corinna, et al.
Publicado: (2021)

A continued learning approach for model‐informed precision dosing: Updating models in clinical practice
por: Maier, Corinna, et al.
Publicado: (2021)

Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study
por: Zander, Johannes, et al.
Publicado: (2016)

Therapeutic Drug Monitoring of Meropenem and Piperacillin in Critical Illness—Experience and Recommendations from One Year in Routine Clinical Practice
por: Scharf, Christina, et al.
Publicado: (2020)

Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients
por: Gan, Yuhong, et al.
Publicado: (2023)

The Role of Non-Enzymatic Degradation of Meropenem—Insights from the Bottle to the Body
por: Liebchen, Uwe, et al.
Publicado: (2021)

Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients
por: Busse, David, et al.
Publicado: (2021)

Software- and TDM-Guided Dosing of Meropenem Promises High Rates of Target Attainment in Critically Ill Patients
por: Chiriac, Ute, et al.
Publicado: (2023)

Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients
por: Kallee, Simon, et al.
Publicado: (2022)

Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study
por: Zoller, Michael, et al.
Publicado: (2014)

Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics
por: Busse, David, et al.
Publicado: (2021)

Cell‐level systems biology model to study inflammatory bowel diseases and their treatment options
por: Stübler, Sabine, et al.
Publicado: (2023)

Optimal loading dose of meropenem before continuous infusion in critically ill patients: a simulation study
por: Liebchen, Uwe, et al.
Publicado: (2021)

Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies
por: Mueller-Schoell, Anna, et al.
Publicado: (2021)

Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
por: Schatz, Lea Marie, et al.
Publicado: (2023)

Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings
por: Minichmayr, Iris K., et al.
Publicado: (2022)

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting
por: Greppmair, Sebastian, et al.
Publicado: (2023)

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function
por: Gijsen, Matthias, et al.
Publicado: (2022)

Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin
por: Falkenhagen, Undine, et al.
Publicado: (2023)

A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non‐small cell lung cancer patients
por: Ojara, Francis Williams, et al.
Publicado: (2023)

Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis
por: Krippendorff, Ben-Fillippo, et al.
Publicado: (2009)

Improving the efficacy for meropenem therapy requires a high probability of target attainment in critically ill infants and children
por: Wang, Zeming, et al.
Publicado: (2022)

Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools
por: Weinelt, Ferdinand Anton, et al.
Publicado: (2022)

C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework
por: Nassar, Yomna M., et al.
Publicado: (2023)

The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome
por: Scharf, Christina, et al.
Publicado: (2020)

Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses
por: Hartung, Niklas, et al.
Publicado: (2021)

Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis
por: Gijsen, Matthias, et al.
Publicado: (2021)

Therapeutic drug monitoring-guided high dose meropenem therapy of a multidrug resistant Acinetobacter baumannii - A case report
por: Liebchen, U., et al.
Publicado: (2019)

Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens
por: Oesterreicher, Zoe, et al.
Publicado: (2017)

Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study
por: Grensemann, Jörn, et al.
Publicado: (2020)

Pharmacodynamic Target Attainment for Meropenem and Piperacillin/Tazobactam Using a PK/PD-based Dosing Calculator in Critically Ill Patients
por: Heil, Emily, et al.
Publicado: (2017)

Does the cytokine adsorber CytoSorb(®) reduce vancomycin exposure in critically ill patients with sepsis or septic shock? a prospective observational study
por: Scharf, Christina, et al.
Publicado: (2022)

Physiology-based toxicokinetic modelling of aluminium in rat and man
por: Hethey, Christoph, et al.
Publicado: (2021)

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data
por: Kluwe, Franziska, et al.
Publicado: (2023)

Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study
por: Grisic, Ana‐Marija, et al.
Publicado: (2020)

2560. Individual Meropenem Epithelial Lining Fluid and Plasma PK/PD Target Attainment in Patients with Pneumonia
por: Rohani, Roxane, et al.
Publicado: (2023)

Pharmacokinetic-Pharmacodynamic Target Attainment Analyses as Support for Meropenem-Vaborbactam Dosing Regimens and Susceptibility Breakpoints
por: Bhavnani, S. M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hrjhp084uhm270jq6p6mqpj3je